Osmolality- and angiotensin-induced responses in the AV3V neurons are affected by estrogen in the ovariectomized rat

被引:8
作者
Akaishi, T
Homma, S
机构
[1] Department of Physiology, Niigata Univ. School of Medicine, Niigata 951
关键词
anteroventral third ventricle (AV3V) neuron; osmotic stimuli; angiotensin; estrogen; rat;
D O I
10.1016/0304-3940(95)12228-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effect of hyperosmolality (300, 320 mosmol/kg H2O) and angiotensin II (A II, 10(-8) and 10(-6) M) was tested on a total of 64 neurons within the periventricular part of the anteroventral third ventricle (AV3V) region in brain slice preparations obtained from ovariectomized (OVX) rats with or without chronic treatment of estradiol-17 beta (E2). Hypertonic perfusion with a 320 mosmol/kg H2O but not a 300 mosmol/kg H2O medium caused a significant increase in the firing discharge rate in OVX animals. Perfusion with either hypertonic medium had no effect in EZ-treated rats. The neuronal firing discharge rate of neurons in OVX rats was increased following perfusion with 10(-6) M A II, but not affected following perfusion with 10(-8) M A II M A II. E2-treated rats, perfusion with neither 10(-8) nor 10(-6) M A II had any effect. These data suggest a dynamic relationship between the ovarian endocrine function and the central mechanisms regulating dipsogenic behavior and/or release of vasopressin in the female rat.
引用
收藏
页码:153 / 156
页数:4
相关论文
共 19 条
[1]   HYPOTHALAMIC OSMOREGULATION FOR VASOPRESSIN RELEASE IN STREPTOZOTOCIN-DIABETIC RATS INVIVO AND INVITRO [J].
AKAISHI, T ;
HOMMA, S .
BRAIN RESEARCH, 1992, 569 (01) :86-92
[2]   ESTROGEN-INDUCED MODULATION OF HYPOTHALAMIC OSMOREGULATION IN FEMALE RATS [J].
AKAISHI, T ;
SAKUMA, Y .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (04) :R924-R929
[3]  
ALBEFESSARD D, 1966, ATLAS STEREOTAXIQUE
[4]   EFFECT OF OVARIAN SEX STEROIDS ON OSMOREGULATION AND VASOPRESSIN SECRETION IN THE RAT [J].
BARRON, WM ;
SCHREIBER, J ;
LINDHEIMER, MD .
AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 250 (04) :E352-E361
[5]   OSMOREGULATION DURING PREGNANCY IN THE RAT - EVIDENCE FOR RESETTING OF THE THRESHOLD FOR VASOPRESSIN SECRETION DURING GESTATION [J].
DURR, JA ;
STAMOUTSOS, B ;
LINDHEIMER, MD .
JOURNAL OF CLINICAL INVESTIGATION, 1981, 68 (02) :337-346
[6]  
FERRIS TF, 1983, RENAL ENDOCRINOLOGY, P462
[7]   DEPENDENCE OF SPONTANEOUS AND ANGIOTENSIN-INDUCED DRINKING IN THE RAT UPON THE ESTROUS-CYCLE AND OVARIAN HORMONES [J].
FINDLAY, ALR ;
FITZSIMONS, JT ;
KUCHARCZYK, J .
JOURNAL OF ENDOCRINOLOGY, 1979, 82 (02) :215-225
[8]  
FREGLY MJ, 1978, FED PROC, V37, P2694
[9]   THE ROLE OF THE ANTEROVENTRAL 3RD VENTRICLE AREA IN THE OSMOTIC CONTROL OF PARAVENTRICULAR NEUROSECRETORY-CELLS [J].
HONDA, K ;
NEGORO, H ;
HIGUCHI, T ;
TADOKORO, Y .
EXPERIMENTAL BRAIN RESEARCH, 1989, 76 (03) :497-502
[10]   ACTIVATION OF NEUROSECRETORY-CELLS BY OSMOTIC STIMULATION OF ANTEROVENTRAL 3RD VENTRICLE [J].
HONDA, K ;
NEGORO, H ;
HIGUCHI, T ;
TADOKORO, Y .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (06) :R1039-R1045