An apigenin-derived xanthine oxidase inhibitor from Palhinhaea cernua

被引：37

作者：

Jiao, Rui H. ^{[1
]}

Ge, Hui M. ^{[1
]}

Shi, Da H. ^{[1
]}

Tan, Ren X. ^{[1
]}

机构：

[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Inst Funct Biomol, Nanjing 210093, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 07期

关键词：

D O I：

10.1021/np060038a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Fractionation of the ethanol extract of Palhinhaea cernua afforded a new (1) and two known p-coumaroylated apigenin glycosides (2, 3) in addition to dillenetin, rhamnazin, alpha-onocerin, beta-sitosterol, and (E)-2-hydroxy-5-methoxycinnamic acid. The structure of compound 1 was elucidated as apigenin-4'-O-(2"-O-p-coumaroyl)-beta-D-glucopyranoside by a combination of its spectroscopic data. The new glycoside 1 inhibits xanthine oxidase (IC50: 23.95 +/- 0.43 mu M) in a competitive-noncompetitive manner with K-i and K-I values of 14.35 and 93.68 mu M, whereas compounds 2 and 3 were inactive. The distribution and significance of acylated flavonoid glycosides are discussed.

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页码：1089 / 1091

页数：3

相关论文

共 39 条

[1] Serum uric acid and cardiovascular events in successfully treated hypertensive patients [J].

Alderman, MH ;

Cohen, H ;

Madhavan, S ;

Kivlighn, S .

HYPERTENSION, 1999, 34 (01) :144-150

[2] NEW ACYLATED APIGENIN 4'-O-BETA-D-GLUCOSIDE FROM THE LEAVES OF LYCOPODIUM-CLAVATUM L [J].

ANSARI, FR ;

ANSARI, WH ;

RAHMAN, W ;

SELIGMANN, O ;

CHARI, VM ;

WAGNER, H ;

OSTERDAHL, BG .

PLANTA MEDICA, 1979, 36 (03) :196-199

[3] Formation of a complex pattern of sinapate esters in Brassica napus seeds, catalyzed by enzymes of a serine carboxypeptidase-like acyltransferase family? [J].

Baumert, A ;

Milkowski, C ;

Schmidt, J ;

Nimtz, M ;

Wray, V ;

Strack, D .

PHYTOCHEMISTRY, 2005, 66 (11) :1334-1345

[4] Covalently linked anthocyanin-flavonol pigments from blue Agapanthus flowers [J].

Bloor, SJ ;

Falshaw, R .

PHYTOCHEMISTRY, 2000, 53 (05) :575-579

[5] Progress towards the discovery of xanthine oxidase inhibitors [J].

Borges, F ;

Fernandes, E ;

Roleira, F .

CURRENT MEDICINAL CHEMISTRY, 2002, 9 (02) :195-217

[6]

BOTTOMLEY W., 1965, NATURE, V207, P1311, DOI 10.1038/2071311b0

[7] Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis [J].

Hooper, DC ;

Spitsin, S ;

Kean, RB ;

Champion, JM ;

Dickson, GM ;

Chaudhry, I ;

Koprowski, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (02) :675-680

[8] Five novel flavonoids from Wasabia japonica [J].

Hosoya, T ;

Yun, YS ;

Kunugi, A .

TETRAHEDRON, 2005, 61 (29) :7037-7044

[9]

Jiangsu College of New Medical, 1996, COMPR DICT TRAD CHIN, P2394

[10] Acylated flavonoid and phenylethanoid glycosides from Marrubium velutinum [J].

Karioti, A ;

Skaltsa, H ;

Heilmann, J ;

Sticher, O .

PHYTOCHEMISTRY, 2003, 64 (02) :655-660

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