Recent advances in sonodynamic approach to cancer therapy

被引：79

作者：

Umemura, S ^{[1
]}

Kawabata, K ^{[1
]}

Sasaki, K ^{[1
]}

Yumita, N ^{[1
]}

Umemura, K ^{[1
]}

Nishigaki, R ^{[1
]}

机构：

[1] TOHO UNIV, FUNABASHI, CHIBA 274, JAPAN

来源：

ULTRASONICS SONOCHEMISTRY | 1996年 / 3卷 / 03期

关键词：

antitumor effect; protoporphyrin; cavitation; sonodynamic therapy; second-harmonic superimposition;

D O I：

10.1016/S1350-4177(96)00024-7

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Chemical agents such as porphyrins were found to be activated by ultrasound, producing significant antitumor effects. Hematoporphyrin (Hp) enhanced ultrasonically induced damage on sarcoma cells and shown a synergistic inhibitory effect on the tumor growth in combination with ultrasound at 2 MHz. Recently, other types of porphyrins such as protoporphyrin were also found to have such sonodynamic activities. Furthermore, it was found that sonochemical reactions can be greatly accelerated by superimposing the second harmonic onto the fundamental. The highest rate of iodine release from aqueous iodide was obtained at an acoustic intensity ratio between 1 MHz and 2 MHz of 1:1 while either one of the frequency components alone could not induce significant iodine release at the same total acoustic intensity. Second-harmonic superimposition in combination with sonodynamically active antitumor agents may have the potential for selective tumor treatment.

引用

页码：S187 / S191

页数：5

共 24 条

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