Detection of malignant mesothelioma in asbestos-exposed individuals: The potential role of soluble mesothelin-related protein

被引：30

作者：

Creaney, J

Robinson, BWS

机构：

[1] Univ Western Australia, Sch Med & Pharmacol, Sir Charles Gairdner Hosp, Nedlands, WA 6009, Australia

[2] Western Australian Inst Med Res, Nedlands, WA, Australia

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2005年 / 19卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.hoc.2005.09.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant mesothelioma (MM) is strongly associated with asbestos exposure. Measurement of soluble mesothelin-related protein (SMRP) levels in the serum may prove valuable as an adjunct to current tests for the diagnosis of MM and for monitoring MM patients for the early detection of disease recurrence. SMRP measures also may be useful in an overall screening program for MM because early results show that some individuals have elevated levels I to 4 years before symptom development. Although individuals with occupational and nonoccupational asbestos exposure are justifiably concerned about their risk of developing MM, consideration must be given to the complex issues surrounding screening for this disease, and a more substantial evaluation of the SMRP marker must be undertaken before deciding to promote a screening program.

引用

页码：1025 / +

页数：17

共 65 条

[1]

ANTMAN KH, 2001, CANC PRINCIPLES PRAC, P1943

[2]

Argani P, 2001, CLIN CANCER RES, V7, P3862

[3] Clinical utility of cytokeratins as tumor markers [J].