Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression

被引：45

作者：

Yi Yongjun ^{[1
,2
]}

Huang Shuyun ^{[1
,2
]}

Chen Lei ^{[1
,2
]}

Chen Xiangrong ^{[1
,3
]}

Yang Zhilin ^{[1
,2
]}

Ke Yiquan ^{[1
,2
]}

机构：

[1] Southern Med Univ, Zhujiang Hosp, Dept Neurosurg, Guangzhou 510282, Guangdong, Peoples R China

[2] Southern Med Univ, Inst Neurosurg, Key Lab Brain Funct Repair & Regenerat Guangdong, Guangzhou 510282, Guangdong, Peoples R China

[3] Fujian Med Univ, Affiliated Hosp 2, Dept Neurosurg, Quanzhou 362000, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 260卷 / 1-2期

基金：

美国国家科学基金会;

关键词：

Microglia; Glioma; Atorvastatin; MT1-MMP; Migration; Invasion; ENDOTHELIAL GROWTH-FACTOR; CELL LUNG CARCINOMAS; NF-KAPPA-B; MATRIX METALLOPROTEINASES; UP-REGULATION; INVASIVENESS; ACTIVATION; INHIBITION;

D O I：

10.1016/j.jneuroim.2013.04.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Microglia, the immune cells of the brain, often present in large numbers in gliomas, where they promote tumor growth and invasiveness. This study found that atorvastatin reduced the pro-tumorigenic effects of microglia on glioma migration and invasion by reducing the microglial expression of membrane type 1 metalloproteinase (MT1-MMP). The results suggest that down-regulation of MT1-MMP is controlled by a p38 MAPK pathway in microglia. Taken together, the results support further research on atorvastatin as a candidate for glioma therapy by targeting microglia. (C) 2013 Elsevier B.V. All rights reserved.

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页码：1 / 8

页数：8

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