Sublethal dose of LPS to pregnant rats induces TNF-alpha tolerance in their 0-day-old offspring

被引:7
作者
Goto, M
Yoshioka, T
Young, RI
Battelino, T
Anderson, CL
Zeller, WP
机构
[1] LOYOLA UNIV, DEPT PATHOL, MAYWOOD, IL 60153 USA
[2] LOYOLA UNIV, DEPT PHYSIOL, MAYWOOD, IL 60153 USA
[3] LOYOLA UNIV, RONALD MCDONALD CHILDRENS HOSP, MAYWOOD, IL 60153 USA
[4] HINES VET AFFAIRS HOSP, RES SERV, HINES, IL 60141 USA
关键词
endotoxin; endotoxic shock; fetus; endotoxin tolerance;
D O I
10.1152/ajpregu.1997.273.3.R1158
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The newborn has high mortality in septic shock. Induction of endotoxin tolerance may prevent endotoxic shack in the newborn. The present study showed that a small dose of Salmonella enteritidis Lipopolysaccharide (S. ent. LPS): Rc mutant Escherichia coli lipopolysaccharide (J5 LPS), or tumor necrosis factor-alpha (TNF-alpha) given to pregnant rats on the 19th day of gestation induced endotoxin tolerance in their 0-day-old offspring. S. ent. LPS or J5 LPS injected into pregnant rats increased plasma endotoxin-like activity in dams, although not in their fetuses, and increased plasma TNF-alpha concentration in both dams and their fetuses. The endotoxin-tolerant newborn rats were also resistant to TNF-alpha. In those newborn rats, an LPS injection increased plasma TNF-alpha concentration and liver TNF-alpha mRNA abundance. These experiments showed that the endotoxin tolerance could be due to TNF-alpha tolerance. In conclusion, prenatal treatment of dams with a small dose of S. ent. LPS, J5 LPS, or TNF-alpha was beneficial in preventing endotoxic shock in the newborn.
引用
收藏
页码:R1158 / R1162
页数:5
相关论文
共 26 条
[1]   SINGLE-DOSE TUMOR-NECROSIS-FACTOR PROTECTION AGAINST ENDOTOXIN-INDUCED SHOCK AND TISSUE-INJURY IN RATS [J].
ALEXANDER, HR ;
DOHERTY, GM ;
BLOCK, MI ;
KRAGEL, PJ ;
JENSEN, JC ;
LANGSTEIN, HN ;
WALKER, E ;
NORTON, JA .
INFECTION AND IMMUNITY, 1991, 59 (11) :3889-3894
[2]   INFECTIONS IN SEVERELY TRAUMATIZED CHILDREN [J].
BELL, LM ;
BAKER, MD ;
BEATTY, D ;
TAYLOR, L .
JOURNAL OF PEDIATRIC SURGERY, 1992, 27 (11) :1394-1398
[3]  
CARVAJAL HF, 1988, BURNS CHILDREN, P228
[4]   ENDOTOXIN TOLERANCE IS ASSOCIATED WITH ALTERED GTP-BINDING PROTEIN FUNCTION [J].
COFFEE, KA ;
HALUSHKA, PV ;
ASHTON, SH ;
TEMPEL, GE ;
WISE, WC ;
COOK, JA .
JOURNAL OF APPLIED PHYSIOLOGY, 1992, 73 (03) :1008-1013
[5]   A CONTROLLED TRIAL OF INTRAVENOUS IMMUNE GLOBULIN TO REDUCE NOSOCOMIAL INFECTIONS IN VERY-LOW-BIRTH-WEIGHT INFANTS [J].
FANAROFF, AA ;
KORONES, SB ;
WRIGHT, LL ;
WRIGHT, EC ;
POLAND, RL ;
BAUER, CB ;
TYSON, JE ;
PHILIPS, JB ;
EDWARDS, W ;
LUCEY, JF ;
CATZ, CS ;
SHANKARAN, S ;
OH, W ;
CASSADY, G ;
BRAUNE, K ;
HACK, M ;
NEWMAN, NS ;
LITTLE, G ;
NATTIE, C ;
BAIN, RP ;
VERTER, J ;
YOUNES, N ;
HAWES, S ;
MURAN, G ;
BANDSTRA, ES ;
MARTINEZ, S ;
YAFFE, SJ ;
MALLOY, M ;
COOKE, R ;
MOORE, J ;
BURCHFIELD, J ;
HORBAR, JD ;
LEAHY, K .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (16) :1107-1113
[6]  
FRIBERGER P, 1985, BACTERIAL ENDOTOXINS, P139
[7]   CHARACTERIZATION AND EXPRESSION OF HUMAN HEPG2 ERYTHROCYTE GLUCOSE-TRANSPORTER GENE [J].
FUKUMOTO, H ;
SEINO, S ;
IMURA, H ;
SEINO, Y ;
BELL, GI .
DIABETES, 1988, 37 (05) :657-661
[8]  
GOTO M, 1992, RES COMMUN CHEM PATH, V76, P249
[9]  
GOTO M, 1994, RES COMMUN MOL PATH, V85, P109
[10]  
GOTO M, 1991, CIRC SHOCK, V35, P60