Structure-activity relationships of novel neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata

被引：30

作者：

Han, Chunguang ^{[1
]}

Qi, Jianhua ^{[1
]}

Ojika, Makoto ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 13期

基金：

日本学术振兴会;

关键词：

linckosides; steroid glycosides; marine natural products; neuritogenic activity;

D O I：

10.1016/j.bmc.2006.02.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Six new steroid glycosides, linckosides F-K, and a related metabolite were isolated from the Okinawan blue starfish Linckia laevigata as mimics or enhancers of nerve growth factor (NGF). Their structures and stereochemistry were elucidated by spectroscopic methods and chemical derivatization. Structure-activity relationships suggest that both a carbon branch modified by a pentose at the side chain and 2'-O-methylxylopyranose at C-3 of the aglycon are important for neuritogenic activity. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4458 / 4465

页数：8

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