Platelet Mimetic Particles for Targeting Thrombi in Flowing Blood

被引：116

作者：

Doshi, Nishit ^{[1
]}

Orje, Jennifer N. ^{[2
]}

Molins, Blanca ^{[2
]}

Smith, Jeffrey W. ^{[3
]}

Mitragotri, Samir ^{[1
]}

Ruggeri, Zaverio M. ^{[2
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA

[2] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

[3] Sanford Burnham Inst, La Jolla, CA USA

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 28期

基金：

美国国家卫生研究院;

关键词：

platelets; targeted drug delivery; polymeric particles; layer-by-layer technique; GPIb; VWF domain; VON-WILLEBRAND-FACTOR; GLYCOPROTEIN IB-ALPHA; SHEAR-STRESS; ADHESION; DOMAIN; AGGREGATION; MECHANISM; COMPLEX; BINDING; DESIGN;

D O I：

10.1002/adma.201200607

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Platelets are a paradigm for a drug carrier in blood owing to their unique physical and biochemical properties. Here, we report the development of synthetic particles that mimic several physical features and important functional properties of platelets. These synthetic platelets have therapeutic and diagnostic applications for platelet associated disorders.

引用

页码：3864 / 3869

页数：6

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