The store-operated calcium current I-CRAC: Nonlinear activation by InsP(3) and dissociation from calcium release

被引：199

作者：

Parekh, AB ^{[1
]}

Fleig, A ^{[1
]}

Penner, R ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM, D-37077 GOTTINGEN, GERMANY

来源：

CELL | 1997年 / 89卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0092-8674(00)80282-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Patch-clamp experiments aimed at determining the relationship between intracellular Ca2+ release and activation of store-operated calcium current I-CRAC reveal that both agonist and InsP(3)-mediated activation of I-CRAC are highly nonlinear, occurring over a narrow concentration range. Ca2+ release and Ca2+ influx can be dissociated, as they possess differential sensitivities to InsP(3): low concentrations induce substantial Ca2+ release without any activation of I-CRAC, whereas micromolar concentrations of InsP(3) are required to activate Ca2+ influx. This suggests functionally distinct stores controlling Ca2+ release and influx and enables cells to switch between sources of Ca2+ to fit best their current needs.

引用

页码：973 / 980

页数：8

共 29 条

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