Quantitative analysis of the role of nanohydroxyapatite (nHA) on 3D-printed PCL/nHA composite scaffolds

被引：43

作者：

Kim, Myoung Hwan ^{[1
]}

Yun, Chulhee ^{[3
,4
]}

Chalisserry, Elna Paul ^{[3
,4
]}

Lee, Yong Wook ^{[2
,3
,4
]}

Kang, Hyun Wook ^{[1
,3
,4
]}

Park, Sang-Hyug ^{[1
,3
,4
]}

Jung, Won-Kyo ^{[1
,3
,4
]}

Oh, Junghwan ^{[1
,3
,4
]}

Nam, Seung Yun ^{[1
,3
,4
]}

机构：

[1] Pukyong Natl Univ, Dept Biomed Engn, Busan, South Korea

[2] Pukyong Natl Univ, Sch Elect Engn, Busan, South Korea

[3] Pukyong Natl Univ, Interdisciplinary Program Marine Bio Elect & Mech, Busan, South Korea

[4] Pukyong Natl Univ, Ctr Marine Integrated Biomed Technol, Plus BK21, Busan, South Korea

来源：

MATERIALS LETTERS | 2018年 / 220卷

基金：

新加坡国家研究基金会;

关键词：

Biomaterials; Bioceramics; Composite materials; Microstructure; CHEMICAL-SYNTHESIS; HYDROXYAPATITE; POLY(EPSILON-CAPROLACTONE); POLYCAPROLACTONE;

D O I：

10.1016/j.matlet.2018.03.025

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

Nanohydroxyapatite (nHA) is a widely accepted bone substitute material due to its biocompatibility and intrinsic osteoconductive properties. For various tissue-engineered applications including 3D-printing fabrication of bone substitutes, composite scaffolds combining calcium phosphate such as nHA with synthetic polymer such as polycaprolactone (PCL) have been extensively explored to enhance the mechanical and physiochemical properties. In this study, 3D-printed PCL/nHA scaffolds were developed using mechanical extrusion-based 3D bioprinter. Scaffold morphology, chemical composition, mechanical strength, cell proliferation, and mineralization were quantitatively analyzed at various concentrations of nHA (0, 10, 20 and 30 wt%). The experimental results suggest essential data to optimize mechanical properties, printability, cellular interactions, and osteoconductivity of 3D-printed PCL/nHA composite scaffolds. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：112 / 115

页数：4

共 15 条

[1]

Processing methodologies for polycaprolactone-hydroxyapatite composites: A review [J].