Pathoadaptive mutations: gene loss and variation in bacterial pathogens

被引：175

作者：

Sokurenko, EV ^{[1
]}

Hasty, DL

Dykhuizen, DE

机构：

[1] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

[2] Univ Tennessee, Dept Neurobiol & Anat, Memphis, TN 38163 USA

[3] Dept Vet Affairs Med Ctr, Res Serv 151, Memphis, TN 38104 USA

[4] SUNY Stony Brook, Dept Ecol & Evolut, Stony Brook, NY 11794 USA

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0966-842X(99)01493-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pathogenicity-adaptive, or pathoadaptive, mutations represent a genetic mechanism for enhancing bacterial virulence without horizontal transfer of specific virulence factors. Pathoadaptive evolution can be important within single infections and for defining the population structure of a pathogenic species.

引用

页码：191 / 195

页数：5

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