Lipids on the move: Simulations of membrane pores, domains, stalks and curves

被引：363

作者：

Marrink, Siewert J. ^{[1
,2
]}

de Vries, Alex H. ^{[1
,2
]}

Tieleman, D. Peter ^{[3
]}

机构：

[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, NL-9747 AG Groningen, Netherlands

[2] Univ Groningen, Zernike Inst Adv Mat, NL-9747 AG Groningen, Netherlands

[3] Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2009年 / 1788卷 / 01期

基金：

加拿大健康研究院;

关键词：

Computer modeling; Molecular dynamics; Biological membrane; Non-lamellar phase; Self-assembly; Phase transformation; Membrane pore; Vesicle; Lipid flip-flop; MOLECULAR-DYNAMICS SIMULATIONS; DISSIPATIVE PARTICLE DYNAMICS; COARSE-GRAINED MODEL; COMPUTER-SIMULATIONS; PHASE-BEHAVIOR; VESICLE FUSION; ION-TRANSPORT; INTERMONOLAYER FRICTION; ANTIMICROBIAL PEPTIDES; MESOSCOPIC SIMULATIONS;

D O I：

10.1016/j.bbamem.2008.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this review we describe the state-of-the-art of computer simulation studies of lipid membranes. We focus on collective lipid-lipid and lipid-protein interactions that trigger deformations of the natural lamellar membrane state, showing that many important biological processes including self-aggregation of membrane components into domains, the formation of non-lamellar phases, and membrane poration and curving, are now amenable to detailed simulation studies. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：149 / 168

页数：20

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