Synthesis of boron-containing cholesterol derivatives for incorporation into unilamellar liposomes and evaluation as potential agents for BNCT

被引：37

作者：

Feakes, DA ^{[1
]}

Spinler, JK ^{[1
]}

Harris, FR ^{[1
]}

机构：

[1] SW Texas State Univ, Dept Chem, San Marcos, TX 78666 USA

来源：

TETRAHEDRON | 1999年 / 55卷 / 37期

关键词：

carborane; boron and compounds; esters; ethers;

D O I：

10.1016/S0040-4020(99)00640-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four carborane-containing derivatives of cholesterol were prepared for incorporation into the bilayer of unilamellar liposomes and evaluation as potential agents for boron neutron capture therapy. The derivatives enable the evaluation of the linker moiety and the type of carborane head group on the bilayer stability and ultimate in vivo tumor specificity. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：11177 / 11186

页数：10

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