Holding damaged DNA together

被引：40

作者：

Rice, PA ^{[1
]}

机构：

[1] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1999年 / 6卷 / 09期

关键词：

D O I：

10.1038/12257

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian X-ray cross-complementing group 1 protein (XRCC1) is an important player in base excision repair of damaged DNA. Two new findings help to elucidate its role - biochemical data suggest that this multidomain protein interacts not only with three different enzymes, but also with the nicked DNA itself, and NMR data reveal the structure of the domain that interacts with both DNA polymerase beta and DNA.

引用

页码：805 / 806

页数：2

共 20 条

[1] Poly ADP-ribosylation:: A DNA break signal mechanism
Althaus, FR
Kleczkowska, HE
Malanga, M
Müntener, CR
Pleschke, JM
Ebner, M
Auer, B
[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 1999, 193 (1-2) : 5 - 11
[2] Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway
Bennett, RAO
Wilson, DM
Wong, D
Demple, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (14) : 7166 - 7169
[3] Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites
Bharati, S
Krokan, HE
Kristiansen, L
Otterlei, M
Slupphaug, G
[J]. NUCLEIC ACIDS RESEARCH, 1998, 26 (21) : 4953 - 4959
[4] A superfamily of conserved domains in DNA damage responsive cell cycle checkpoint proteins
Bork, P
Hofmann, K
Bucher, P
Neuwald, AF
Altschul, SF
Koonin, EV
[J]. FASEB JOURNAL, 1997, 11 (01) : 68 - 76
[5] XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly(ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro
Caldecott, KW
Aoufouchi, S
Johnson, P
Shall, S
[J]. NUCLEIC ACIDS RESEARCH, 1996, 24 (22) : 4387 - 4394
[6] AN INTERACTION BETWEEN THE MAMMALIAN DNA-REPAIR PROTEIN XRCC1 AND DNA LIGASE-III
CALDECOTT, KW
MCKEOWN, CK
TUCKER, JD
LJUNGQUIST, S
THOMPSON, LH
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (01) : 68 - 76
[7] From BRCA1 to RAP1: A widespread BRCT module closely associated with DNA repair
Callebaut, I
Mornon, JP
[J]. FEBS LETTERS, 1997, 400 (01): : 25 - 30
[8] Poly(ADP-ribose)polymerase: A guardian of the genome that facilitates DNA repair by protecting against DNA recombination
Chatterjee, S
Berger, SJ
Berger, NA
[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 1999, 193 (1-2) : 23 - 30
[9] Marintchev A, 1999, NAT STRUCT BIOL, V6, P884
[10] XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage
Masson, M
Niedergang, C
Schreiber, V
Muller, S
Menissier-de Murcia, J
de Murcia, G
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (06) : 3563 - 3571

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