Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment

被引：87

作者：

Holmes, ML ^{[1
]}

Carotta, S ^{[1
]}

Corcoran, LM ^{[1
]}

Nutt, SL ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

来源：

GENES & DEVELOPMENT | 2006年 / 20卷 / 08期

关键词：

B-cell commitment; Pax5; Flt3; transcriptional repression; pro-B cell;

D O I：

10.1101/gad.1396206

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Early B-lymphopoiesis requires the growth-factor receptors, IL-7R and Flt3, and the activity of a number of transcription factors. One factor, Pax5, is required for commitment to the B-cell lineage, although the molecular mechanism by which this occurs is unknown. We demonstrate here that an important function of Pax5 is to repress Flt3 transcription in B-cell progenitors, as Pax5-deficient pro-B cells express abundant Flt3 that is rapidly silenced upon the reintroduction of Pax5, whereas enforced expression of Flt3 in wild-type progenitors significantly impairs B-cell development. These findings demonstrate that the repression of Flt3 by Pax5 is essential for normal B-lymphopoiesis.

引用

页码：933 / 938

页数：6

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