Active viremia in rotavirus-infected mice

被引:36
作者
Blutt, Sarah E.
Fenaux, Martijn
Warfield, Kelly L.
Greenberg, Harry B.
Conner, Margaret E.
机构
[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA
[2] Stanford Univ, Sch Med, Dept Gastroenterol, Palo Alto, CA 94304 USA
[3] Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA
关键词
D O I
10.1128/JVI.00329-06
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Rotavirus circulates extraintestinally in animals used as models for rotavirus infection and in children. Rotavirus infection in mice was used to define host or viral factors that affect rotavirus viremia. Antigenemia was observed with homologous and heterologous rotaviruses, and neither age nor mouse strain genetics altered the occurrence of rotavirus antigenemia or viremia. Rotavirus RNA and infectious virus were present in sera and associated with the plasma fraction of blood in all infected mice. These findings indicate that antigenemia/viremia occurs routinely in rotavirus infections and imply that infectious rotavirus has access to any extraintestinal cell within contact of blood.
引用
收藏
页码:6702 / 6705
页数:4
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