Relationship between plasma carotenoids and prostate cancer

被引:28
作者
Chang, S
Erdman, JW
Clinton, SK
Vadiveloo, M
Strom, SS
Yamamura, Y
Duphorne, CM
Spitz, MR
Amos, CI
Contois, JH
Gu, X
Babaian, RJ
Scardino, PT
Hursting, SD
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Epidemiol, Unit 1365, Houston, TX 77030 USA
[2] Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA
[3] Ohio State Univ, Coll Med, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USA
[4] NCI, Div Canc Prevent, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
[5] Univ Texas, MD Anderson Canc Ctr, Dept Urol, Houston, TX 77030 USA
[6] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2005年 / 53卷 / 02期
关键词
D O I
10.1207/s15327914nc5302_1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Carotenoids, particularly lycopene, are thought to decrease prostate cancer risk, but the relationship between plasma carotenoid concentrations and risk in various populations has not been well characterized Comparing 118 non-Hispanic Caucasian men mainly from southeast Texas with nonmetastatic prostate cancer with 52 healthy men from the same area, we conducted a case-control analysis evaluating associations between risk and plasma levels of total carotenoids, beta-cryptoxanthin, alpha- and trans-beta-carotene, lutein and zeaxanthin, total lycopenes, trans-lycopene, total cis-lycopenes, and cis-lycopene isoforms 1, 2, 3, and 5. Risk for men with high plasma levels of alpha-carotene, trans-beta-carotene, beta-cryptoxanthin, and lutein and zeaxanthin was less than half that for those with lower levels. In contrast, we observed no significant associations for total lycopenes, all-trans-lycopene, and cis-lycopene isomer peaks 2, 3, and 5, although high levels of cis-lycopene isomer peak 1 were inversely associated with risk. Analysis of men with aggressive disease (Gleason scores of >= 7, n=88) vs. less aggressive cases (Gleason scores of < 7, n=30)failed to reveal significant associations between carotenoid levels and the risk of diagnosis with aggressive disease. These findings suggest that, in these men, higher circulating levels of beta-cryptoxanthin, alpha-carotene, trans-beta-carotene, and lutein and zeaxanthin may contribute to lower prostate cancer risk but not to disease progression.
引用
收藏
页码:127 / 134
页数:8
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