Influence of new late effects on quality of life over time in Hodgkin lymphoma Survivors: a longitudinal survey study

被引:23
作者
Khimani, N. [1 ,2 ,3 ]
Chen, Y. -H. [1 ,2 ,3 ]
Mauch, P. M. [1 ,2 ,3 ]
Recklitis, C. [1 ,2 ,3 ]
Diller, L. [1 ,2 ,3 ]
Silver, B. [1 ,2 ,3 ]
Ng, A. K. [1 ,2 ,3 ]
机构
[1] Brigham & Womens Hosp, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA
[2] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA
[3] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
关键词
fatigue; Hodgkin lymphoma; quality of life; survivorship; LONG-TERM SURVIVORS; DISEASE SURVIVORS; PSYCHOLOGICAL DISTRESS; FATIGUE; CANCER; CHEMOTHERAPY;
D O I
10.1093/annonc/mds243
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Long-term Hodgkin lymphoma (HL) survivors are known to have diminished quality of life (QoL). However, limited data are available on temporal changes in QoL and factors associated with the changes. In 2010, we conducted a follow-up questionnaire study on 273 HL survivors who participated in a 2003 questionnaire study on late effects after HL. The questionnaire items were limited to new late complications and reassessment of QoL and fatigue level, using the Short Form 36 (SF-36) and the Functional Assessment of Chronic Illness Therapy-Fatigue instruments, respectively. We compared the results from the 2003 and the 2010 questionnaires, and QoL score changes between survivors with and without new late complications during the 7-year period. There was a significant decline in the SF-36 Physical Component Summary score (median change, -1.8; P < 0.0001) over the time period. The decline was significantly greater among survivors with a new cardiac (P = 0.005) or pulmonary (P < 0.0001) complication, compared with those without any new complications. The survivors reporting new cardiac complications also experienced significantly greater worsening of fatigue scores (P = 0.004). The significant association between the development of new cardiopulmonary complications and decline in QoL and energy level of HL survivors provides further support for current efforts to reduce treatment to limit late effects.
引用
收藏
页码:226 / 230
页数:5
相关论文
共 27 条
[1]   PSYCHOSOCIAL OUTCOMES OF CANCER - A COMPARATIVE-ANALYSIS OF HODGKINS-DISEASE AND TESTICULAR CANCER [J].
BLOOM, JR ;
FOBAIR, P ;
GRITZ, E ;
WELLISCH, D ;
SPIEGEL, D ;
VARGHESE, A ;
HOPPE, R .
JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (05) :979-988
[2]   Quality of life of long-term survivors with Hodgkin lymphoma after high-dose chemotherapy, autologous stem cell transplantation, and conventional chemotherapy [J].
Brandt, Juliane ;
Dietrich, Sascha ;
Meissner, Julia ;
Neben, Kai ;
Ho, Anthony D. ;
Witzens-Harig, Mathias .
LEUKEMIA & LYMPHOMA, 2010, 51 (11) :2012-2020
[3]   Ongoing improvement in long-term survival of patients with Hodgkin disease at all ages and recent catch-up of older patients [J].
Brenner, Hermann ;
Gondos, Adam ;
Pulte, Dianne .
BLOOD, 2008, 111 (06) :2977-2983
[4]   Reduced Treatment Intensity in Patients with Early-Stage Hodgkin's Lymphoma [J].
Engert, Andreas ;
Pluetschow, Annette ;
Eich, Hans Theodor ;
Lohri, Andreas ;
Doerken, Bernd ;
Borchmann, Peter ;
Berger, Bernhard ;
Greil, Richard ;
Willborn, Kay C. ;
Wilhelm, Martin ;
Debus, Juergen ;
Eble, Michael J. ;
Soekler, Martin ;
Ho, Antony ;
Rank, Andreas ;
Ganser, Arnold ;
Truemper, Lorenz ;
Bokemeyer, Carsten ;
Kirchner, Hartmut ;
Schubert, Joerg ;
Kral, Zdenek ;
Fuchs, Michael ;
Mueller-Hermelink, Hans-Konrad ;
Mueller, Rolf-Peter ;
Diehl, Volker .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (07) :640-652
[5]   Chemotherapy plus involved-field radiation in early-stage Hodgkin's disease [J].
Ferme, Christophe ;
Eghbali, Houchingue ;
Meerwaldt, Jacobus H. ;
Rieux, Chantal ;
Bosq, Jacques ;
Berger, Francoise ;
Girinsky, Theodore ;
Brice, Pauline ;
van't Veer, Mars B. ;
Walewski, Jan A. ;
Lederlin, Pierre ;
Tirelli, Umberto ;
Carde, Patrice ;
Van den Neste, Eric ;
Gyan, Emmanuel ;
Monconduit, Mathieu ;
Divine, Marine ;
Raemaekers, John M. M. ;
Salles, Gilles ;
Noordijk, Evert M. ;
Creemers, Geert-Jan ;
Gabarre, Jean ;
Hagenbeek, Anton ;
Reman, Oumedaly ;
Blanc, Michel ;
Thomas, Jose ;
Vie, Brigitte ;
Kluin-Nelemans, Johanna C. ;
Viseu, Fernando ;
Baars, Joke W. ;
Poortmans, Philip ;
Lugtenburg, Pieternella J. ;
Carrie, Christian ;
Jaubert, Jerome ;
Henry-Amar, Michel .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (19) :1916-1927
[6]   PSYCHOSOCIAL PROBLEMS AMONG SURVIVORS OF HODGKINS-DISEASE [J].
FOBAIR, P ;
HOPPE, RT ;
BLOOM, J ;
COX, R ;
VARGHESE, A ;
SPIEGEL, D .
JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (05) :805-814
[7]   Health status and quality of life in patients with early-stage Hodgkin's disease treated on Southwest Oncology Group study 9133 [J].
Ganz, PA ;
Moinpour, CM ;
Pauler, DK ;
Kornblith, AB ;
Gaynor, ER ;
Balcerzak, SP ;
Gatti, GS ;
Erba, HP ;
McCoy, S ;
Press, OW ;
Fisher, RI .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (18) :3512-3519
[8]   Quality of life and psychological well-being in Spanish long-term survivors of Hodgkin's disease:: results of a controlled pilot study [J].
Gil-Fernández, JJ ;
Ramos, C ;
Tamayo, AT ;
Tomás, JF ;
Figuera, A ;
Arranz, R ;
Martínez-Chamorro, C ;
Fernández-Rañada, JM .
ANNALS OF HEMATOLOGY, 2003, 82 (01) :14-18
[9]   Retrospective assessment of quality of life and treatment outcome in patients with Hodgkin's disease from 1969 to 1994 [J].
Greil, R ;
Holzner, B ;
Kemmler, G ;
Kopp, M ;
Buchowski, A ;
Oberaigner, W ;
Fritsch, E ;
Dirnhofer, S ;
Rueffer, U ;
Diehl, V ;
Sperner-Unterweger, B .
EUROPEAN JOURNAL OF CANCER, 1999, 35 (05) :698-706
[10]   Quality of life after successful treatment of early-stage Hodgkin's lymphoma: 10-year follow-up of the EORTC-GELA H8 randomised controlled trial [J].
Heutte, Natacha ;
Flechtner, Henning H. ;
Mounier, Nicolas ;
Mellink, Wilhelmina A. M. ;
Meerwaldt, Jacobus H. ;
Eghbali, Houchingue ;
van't Veer, Mars B. ;
Noordijk, Evert M. ;
Kluin-Nelemans, Johanna C. ;
Lampka, Elzbieta ;
Thomas, Jose ;
Lugtenburg, Pieternella J. ;
Viterbo, Luisa ;
Carde, Patrice ;
Hagenbeek, Anton ;
van der Maazen, Richard W. M. ;
Smit, Wilma G. J. M. ;
Brice, Pauline ;
Kooy, Marinus van Marwijk ;
Baars, Johanna W. ;
Poortmans, Philip ;
Tirelli, Umberto ;
Leeksma, Onno C. ;
Tomsic, Radka ;
Feugier, Pierre ;
Salles, Gilles ;
Gabarre, Jean ;
Kersten, Marie Jose ;
Van Den Neste, Eric ;
Creemers, Geert-Jan M. ;
Gaillard, Isabelle ;
Meijnders, Paul ;
Tertian, Gerard ;
Reman, Oumedaly ;
Muller, Hein P. ;
Troncy, Jacques ;
Blanc, Michel ;
Schroyens, Wilfried ;
Voogt, Paul J. ;
Wijermans, Pierre ;
Rieux, Chantal ;
Ferme, Christophe ;
Henry-Amar, Michel .
LANCET ONCOLOGY, 2009, 10 (12) :1160-1170