(2-phenyl-1,3,2]dithiarsolan-4-yl)-methanol derivatives show in vitro antileukemic activity

被引：14

作者：

Gibaud, S

Alfonsi, R

Mutzenhardt, P

Fries, I

Astier, A

机构：

[1] Univ Henri Poincare, Fac Pharm, EA 3452, Lab Pharm Clin, F-54000 Nancy, France

[2] Univ Henri Poincare, Fac Sci, RMN, Serv Commun, F-54506 Vandoeuvre Les Nancy, France

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2006年 / 691卷 / 05期

关键词：

arsenic; melarsoprol; arsthinol; leukemia; toxicity;

D O I：

10.1016/j.jorganchem.2005.11.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The antileukemic activity of a series of (2-Phenyl-[1,3,2]dithiarsolan-4-yl)-methanol derivatives was tested on K562 and U937 human leukemia cell lines. Their systemic toxicity was estimated by the corresponding LD50 on mice. The cytotoxic activity of each derivative was significantly better than that of arsenic trioxide and the therapeutic index (T.I. = LD50/IC50) was improved. No correlation between log P and the activity or the toxicity was found. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：1081 / 1084

页数：4

共 18 条

[1] Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: activation of caspases and down-regulation of Bcl-2 protein [J].