Vaccination with Live Plasmodium yoelii Blood Stage Parasites under Chloroquine Cover Induces Cross-Stage Immunity against Malaria Liver Stage

被引：73

作者：

Belnoue, Elodie ^{[2
,3
]}

Voza, Tatiana ^{[7
,8
]}

Costa, Fabio T. M. ^{[2
,3
,9
]}

Gruener, Anne Charlotte ^{[1
,2
,3
]}

Mauduit, Marjorie ^{[2
,3
]}

Rosa, Daniela Santoro ^{[2
,3
]}

Depinay, Nadya ^{[2
,3
]}

Kayibanda, Michele ^{[2
,3
]}

Vigario, Ana Margarida ^{[2
,3
]}

Mazier, Dominique ^{[4
,6
]}

Snounou, Georges ^{[4
,5
,7
]}

Sinnis, Photini ^{[5
,8
]}

Renia, Laurent ^{[1
,2
,3
]}

机构：

[1] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore 138648, Singapore

[2] Univ Paris 05, CNRS, Dept Immunol, Inst Cochin,Unite Mixte Rech 8104, Paris, France

[3] INSERM, U567, F-75654 Paris 13, France

[4] INSERM, U511, F-75654 Paris 13, France

[5] Univ Paris 06, Fac Med Pitie Salpetriere, F-75252 Paris 05, France

[6] Ctr Hosp Univ Pitie Salpetriere, AP HP, Paris, France

[7] Museum Natl Hist Nat, Inst Fed Res 101, CNRS,Unite Sci Museum 0307, Equipe Parasitol Comparee & Modeles Expt, F-75231 Paris, France

[8] NYU, Sch Med, Dept Med Parasitol, New York, NY 10010 USA

[9] Univ Estadual Campinas, Dept Parasitol, Campinas, SP, Brazil

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 181卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.4049/jimmunol.181.12.8552

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Immunity to malaria has long been thought to be stage-specific. In this study we show that immunization of BALB/c mice with live erythrocytes infected with nonlethal strains of Plasmodium yoelii under curative chloroquine cover conferred protection not only against challenge by blood stage parasites but also against sporozoite challenge. This cross-stage protection was dose-dependent and long lasting. CD4(+) and CD8(+) T cells inhibited malaria liver but not blood stage. Their effect was mediated partially by IFN-gamma, and was completely dependent of NO. Abs against both pre-erythrocytic and blood parasites were elicited and were essential for protection against blood stage and liver stage parasites. Our results suggest that Ags shared by liver and blood stage parasites can be the foundation for a malaria vaccine that would provide effective protection against both pre-erythrocytic and erythrocytic asexual parasites found in the mammalian host. The Journal of Immunology, 2008, 181: 8552-8558.

引用

页码：8552 / 8558

页数：7

共 55 条

[1]

Protective T cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment [J].