The ABCs of membrane transporters in health and disease (SLC series): Introduction

被引：510

作者：

Hediger, Matthias A. ^{[1
,2
]}

Clemencon, Benjamin ^{[1
,2
]}

Burrier, Robert E. ^{[2
,3
]}

Bruford, Elspeth A. ^{[4
]}

机构：

[1] Univ Bern, Inst Biochem & Mol Med, CH-3012 Bern, Switzerland

[2] Univ Bern, NCCR TransCure, Swiss Natl Ctr Competence Res, CH-3012 Bern, Switzerland

[3] Stemina Biomarker Discovery, Madison, WI USA

[4] EMBL EBI, HUGO Gene Nomenclature Comm, Hinxton CB10 1SD, Cambs, England

来源：

MOLECULAR ASPECTS OF MEDICINE | 2013年 / 34卷 / 2-3期

基金：

瑞士国家科学基金会;

关键词：

Transporter; Carrier; Nomenclature; Solute carrier genes; SLC; Exchanger; Cotransporter; Uniporter; Symporter; Antiporter; Ion transport; Solute transport; Coupled transport; Channel; Pump; ABC transporter; Aquaporin; Water soluble vitamins; Structure; Membrane proteins; Glucose transporter; Diabetes; GLUT1; SLC2A1; VITAMIN-C TRANSPORTER; MITOCHONDRIAL ADP/ATP CARRIER; FOLATE RECEPTOR-ALPHA; ASCORBIC-ACID; FUNCTIONAL-CHARACTERIZATION; BACTERIAL HOMOLOG; CRYSTAL-STRUCTURE; EXPRESSION CLONING; ZINC TRANSPORTERS; MOLECULAR-BASIS;

D O I：

10.1016/j.mam.2012.12.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease. The SLC (solute carrier) gene series has grown to now include 52 families and 395 transporter genes in the human genome. A list of these genes can be found at the HUGO Gene Nomenclature Committee (HGNC) website (see www.genenames.org/genefamilies/SLC). This special issue features mini-reviews for each of these SLC families written by the experts in each field. The existing online resource for solute carriers, the Bioparadigms SLC Tables (www.bioparadigms.org), has been updated and significantly extended with additional information and cross-links to other relevant databases, and the nomenclature used in this database has been validated and approved by the HGNC. In addition, the Bioparadigms SLC Tables functionality has been improved to allow easier access by the scientific community. This introduction includes: an overview of all known SLC and "non-SLC" transporter genes; a list of transporters of water soluble vitamins; a summary of recent progress in the structure determination of transporters (including GLUT1/SLC2A1); roles of transporters in human diseases and roles in drug approval and pharmaceutical perspectives. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：95 / 107

页数：13

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