BRCA1 and BRCA2 in hereditary breast cancer

被引：24

作者：

Scully, R

Puget, N

机构：

[1] Beth Israel Deaconess Med Ctr, Canc Biol Program, Dept Hematol Oncol, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA 02215 USA

来源：

BIOCHIMIE | 2002年 / 84卷 / 01期

关键词：

breast cancer; DNA repair; homologous recombination; tumor suppressor genes; BRCA1; BRCA2;

D O I：

10.1016/S0300-9084(01)01359-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hereditary breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2, have established roles in genome integrity maintenance and in the control of homologous recombination. Recent work has produced valuable insights into the mechanisms of action of the gene products. This review summarizes some of these advances, and attempts to place them in the context of known functions of the genes. (C) 2002 Societe francaise de biochimie et biologie moleculaire / Editions scientifiques et medicales Elsevier SAS.

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收藏

页码：95 / 102

页数：8

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