Multicenter Study of Isavuconazole MIC Distributions and Epidemiological Cutoff Values for Aspergillus spp. for the CLSI M38-A2 Broth Microdilution Method

被引：76

作者：

Espinel-Ingroff, A. ^{[1
]}

Chowdhary, A. ^{[2
]}

Gonzalez, G. M. ^{[3
]}

Lass-Floerl, C. ^{[4
]}

Martin-Mazuelos, E. ^{[5
]}

Meis, J. ^{[6
,7
]}

Pelaez, T. ^{[8
]}

Pfaller, M. A. ^{[9
]}

Turnidge, J. ^{[10
]}

机构：

[1] VCU Med Ctr, Richmond, VA USA

[2] Univ Delhi, Vallabhbhai Patel Chest Inst, Delhi 110007, India

[3] Univ Autonoma Nuevo Leon, Monterrey, Nuevo Leon, Mexico

[4] Med Univ Innsbruck, A-6020 Innsbruck, Austria

[5] Hosp Univ Valme, Seville, Spain

[6] Canisius Wilhelmina Hosp, Nijmegen, Netherlands

[7] Radboud Univ Nijmegen, NL-6525 ED Nijmegen, Netherlands

[8] Univ Complutense, Fac Med, Hosp Gen Univ Gregorio Maranon, E-28040 Madrid, Spain

[9] JMI Labs, North Liberty, IA USA

[10] Univ Adelaide, Adelaide, SA, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 08期

关键词：

CELL TRANSPLANT RECIPIENTS; IN-VITRO ACTIVITY; EUROPEAN COMMITTEE; AZOLE RESISTANCE; AMPHOTERICIN-B; CYP51A GENE; FUMIGATUS; SUSCEPTIBILITY; TRIAZOLE; VORICONAZOLE;

D O I：

10.1128/AAC.00636-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Epidemiological cutoff values (ECVs) were established for the new triazole isavuconazole and Aspergillus species wild-type (WT) MIC distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) that were defined with 855 Aspergillus fumigatus, 444 A. flavus, 106 A. nidulans, 207 A. niger, 384 A. terreus, and 75 A. versicolor species complex isolates; 22 Aspergillus section Usti isolates were also included. CLSI broth microdilution MIC data gathered in Europe, India, Mexico, and the United States were aggregated to statistically define ECVs. ECVs were 1 mu g/ml for the A. fumigatus species complex, 1 mu g/ml for the A. flavus species complex, 0.25 mu g/ml for the A. nidulans species complex, 4 mu g/ml for the A. niger species complex, 1 mu g/ml for the A. terreus species complex, and 1 mu g/ml for the A. versicolor species complex; due to the small number of isolates, an ECV was not proposed for Aspergillus section Usti. These ECVs may aid in detecting non-WT isolates with reduced susceptibility to isavuconazole due to cyp51A (an A. fumigatus species complex resistance mechanism among the triazoles) or other mutations.

引用

页码：3823 / 3828

页数：6

共 43 条

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