Chemistry of hypusine formation on eukaryotic initiation factor 5A in biological systems

被引：9

作者：

Chen, KY

Jao, DL

机构：

[1] Rutgers State Univ, Dept Chem, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Grad Program Mol Biosci, Piscataway, NJ 08854 USA

[3] Canc Inst New Jersey, Piscataway, NJ 08854 USA

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 1999年 / 46卷 / 05期

关键词：

hypusine; eIF-5A; deoxyhypusine synthase;

D O I：

10.1002/jccs.199900100

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hypusine, an unusual amino acid, is derived from the hydrolysis of eukaryotic initiation factor SA (eIF-5A), the only cellular protein known to contain hypusine residue. Hypusine residue is formed through a spermidine-dependent posttranslational modification of eIF-5A at a specific lysine residue. Each mature eIF-5A molecule contains only one hypusine. Hypusine formation on eIF-5A is essential for cell survival and proliferation. The biochemistry of hypusine formation has, been actively investigated in a number of leading laboratories during the past decade. The precise functional role of eIF-5A remains a mystery. This paper reviews recent progress in the study of the biochemistry of hypusine formation and offers speculation on the possible function of eIF-5A.

引用

页码：727 / 734

页数：8

共 40 条

[1] DIFFERENCES IN POLYAMINE METABOLISM OF THE UNDIFFERENTIATED AND DIFFERENTIATED NEURO-BLASTOMA CELLS - METABOLIC LABELING OF AN 18000-MR PROTEIN BY [PUTRESCINE-C-14 AND THE CONVERSION OF PUTRESCINE TO GABA [J].