Assembly of polypeptide-functionalized gold nanoparticles through a heteroassociation- and folding-dependent bridging

被引：44

作者：

Aili, Daniel ^{[1
]}

Enander, Karin ^{[1
]}

Baltzer, Lars ^{[2
]}

Liedberg, Bo ^{[1
]}

机构：

[1] Linkoping Univ, Div Sensor Sci & Mol Phys, Dept Phys Chem & Biol, SE-58183 Linkoping, Sweden

[2] Uppsala Univ, Div Organ Chem, Dept Biochem & Organ Chem, BMC, SE-75123 Uppsala, Sweden

来源：

NANO LETTERS | 2008年 / 8卷 / 08期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1021/nl8014796

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold nanoparticles were functionalized with a synthetic polypeptide, de novo-designed to associate with a charge complementary linker polypeptide in a folding-dependent manner. A heterotrimeric complex that folds into two disulphide-linked four-helix bundles is formed when the linker polypeptide associates with two of the immobilized peptides. The heterotrimer forms in between separate particles and induces a rapid and extensive aggregation with a well-defined interpartide spacing. The aggregated particles are redispersed when the disulphide bridge in the linker polypeptide is reduced.

引用

页码：2473 / 2478

页数：6

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