Protective immunity to nematode infection is induced by CTLA-4 blockade

被引：95

作者：

McCoy, K ^{[1
]}

Camberis, M ^{[1
]}

LeGros, G ^{[1
]}

机构：

[1] WELLINGTON SCH MED,MALAGHAN INST MED RES,WELLINGTON,NEW ZEALAND

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1997年 / 186卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1084/jem.186.2.183

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recent observation that neutralization or genetic deletion of the T lymphocyte receptor CTLA-4 allows enhanced T cell reactivity offers new opportunities for immunotherapy against infectious agents. We used a neutralizing antibody to block CTLA-4 interaction with its ligands CD80 and CD86 during infection of mice with the nematode, Nippostrongylus brasiliensis. CTLA-4 blockade greatly enhanced and accelerated the T cell immune response to N. brasiliensis, resulting in a profound reduction in adult worm numbers and early termination of parasite egg production. The ability of CTLA-4 blockade to accelerate primary immune responses to a protective level during an acute infection indicates its potential as an immunotherapeutic tool for dealing with infectious agents.

引用

页码：183 / 187

页数：5

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