Decapping the message: a beginning or an end

被引：52

作者：

Liu, H ^{[1
]}

Kiledjian, M ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Cell Biol Neurosci, Piscataway, NJ 08854 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷

关键词：

decapping enzyme; histidine triad motif (HIT motif); mRNA decay; Nudix motif;

D O I：

10.1042/BST0340035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Removal of the mRNA 5' cap is an important step in the regulation of mRNA stability. mRNAs are degraded by at least two distinct exonucleolytic decay pathways, one from the 5' end, and the second from the 3' end. Two major cellular decapping enzymes have been identified, and each primarily functions in one of the two decay pathways. The Dcp2 decapping enzyme utilizes capped mRNA as substrate and hydrolyses the cap to release m(7)GDP (N7-methyl GDP), while a scavenger decapping enzyme, DcpS utilizes cap dinucleotides or capped oligonucleotides as substrate and releases m(7)GMP (N7-methyl GMP). In this review, we will highlight the function of different decapping enzymes and their role in mRNA turnover.

引用

页码：35 / 38

页数：4

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