Lycorine induces apoptosis and down-regulation of Mcl-1 in human leukemia cells

被引：106

作者：

Liu, Xiao-shan ^{[1
]}

Jiang, Jikai ^{[1
]}

Jiao, Xiao-yang ^{[2
]}

Wu, Ying-e ^{[2
]}

Lin, Jing-hua ^{[2
]}

Cai, Ying-mu ^{[2
]}

机构：

[1] Shantou Univ, Sch Med, Ctr Mol Biol, Shantou 515031, Peoples R China

[2] Shantou Univ, Affiliated Hosp 1, Sch Med, Dept Lab Med, Shantou 515031, Peoples R China

来源：

CANCER LETTERS | 2009年 / 274卷 / 01期

关键词：

Lycorine; Mcl-1; Apoptosis; Leukemia; PROTEIN-SYNTHESIS; INHIBITION; CASPASES; KINASE; DIFFERENTIATION; EXPRESSION; ALKALOIDS; CLEAVAGE; SURVIVAL; FAMILY;

D O I：

10.1016/j.canlet.2008.08.029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Lycorine is an alkaloid isolated from the bulb of the Amaryllidaceae Lycoris. Here, we report that treatment with lycorine resulted in survival inhibition and apoptosis induction in human leukemia cell lines. Lycorine induced apoptosis in human leukemia cells via intrinsic mitochondira pathway and caused a rapid-turnover of protein level of Mcl-1 which Occurred before caspases activation. Furthermore, pronounced apoptosis accompanied by the clown-regulation of Mcl-1 was also observed in blasts from patients with acute myeloid leukemia. Our findings suggest that lycorine may be a good candidate therapeutic agent against leukemia in worth of further evaluation. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：16 / 24

页数：9

共 41 条

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