Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility

被引：38

作者：

Cabrera, SM ^{[1
]}

Chavez, CM ^{[1
]}

Corley, SR ^{[1
]}

Kitto, MR ^{[1
]}

Butt, AE ^{[1
]}

机构：

[1] Calif State Univ San Bernardino, Dept Psychol, San Bernardino, CA 92407 USA

来源：

BEHAVIORAL NEUROSCIENCE | 2006年 / 120卷 / 02期

关键词：

192; IgG-saporin; acetylcholine; Alzheimer's disease; basal forebrain; serial reversal;

D O I：

10.1037/0735-7044.120.2.298

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];

摘要：

The authors tested the hypothesis that the cholinergic nucleus basalis magnocellularis (NBM) is involved in solving problems requiring cognitive flexibility. Rats with 192 IgG-saporin lesions of the NBM were assessed for perseveration (i.e., cognitive inflexibility) in the serial reversal of an operant discrimination and during subsequent extinction testing. It was hypothesized that the NBM lesion and control groups would not differ in the acquisition of the initial, simple discrimination, because this task does not demand cognitive flexibility. In contrast, it was hypothesized that the NBM lesion group would show perseveration during serial reversal and extinction testing. Results generally supported these hypotheses, suggesting that the NBM plays an important role in mediating cognitive flexibility.

引用

页码：298 / 306

页数：9

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