Optic Ataxia: From Balint's Syndrome to the Parietal Reach Region

被引：80

作者：

Andersen, Richard A. ^{[1
]}

Andersen, Kristen N. ^{[2
,3
]}

Hwang, Eun Jung ^{[4
]}

Hauschild, Markus ^{[1
]}

机构：

[1] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

[2] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Pediat, Los Angeles, CA 90095 USA

[4] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA

来源：

NEURON | 2014年 / 81卷 / 05期

关键词：

POSTERIOR CORTICAL ATROPHY; LATERAL INTRAPARIETAL AREA; EYE-HAND COORDINATION; REVERSIBLE ENCEPHALOPATHY SYNDROME; SACCADE-RELATED ACTIVITY; MACAQUE MONKEY; VISUOMOTOR TRANSFORMATIONS; FUNCTIONAL-ORGANIZATION; ALZHEIMERS-DISEASE; ASSOCIATION CORTEX;

D O I：

10.1016/j.neuron.2014.02.025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Optic ataxia is a high-order deficit in reaching to visual goals that occurs with posterior parietal cortex (PPC) lesions. It is a component of Balint's syndrome that also includes attentional and gaze disorders. Aspects of optic ataxia are misreaching in the contralesional visual field, difficulty preshaping the hand for grasping, and an inability to correct reaches online. Recent research in nonhuman primates (NHPs) suggests that many aspects of Balint's syndrome and optic ataxia are a result of damage to specific functional modules for reaching, saccades, grasp, attention, and state estimation. The deficits from large lesions in humans are probably composite effects from damage to combinations of these functional modules. Interactions between these modules, either within posterior parietal cortex or downstream within frontal cortex, may account for more complex behaviors such as hand-eye coordination and reach-to-grasp.

引用

页码：967 / 983

页数：17

共 134 条

[1] Intentional maps in posterior parietal cortex [J].

Andersen, RA ;

Buneo, CA .

ANNUAL REVIEW OF NEUROSCIENCE, 2002, 25 :189-220

[2]

ANDERSEN RA, 1987, EXP BRAIN RES, V67, P316

[3] ENCODING OF SPATIAL LOCATION BY POSTERIOR PARIETAL NEURONS [J].

ANDERSEN, RA ;

ESSICK, GK ;

SIEGEL, RM .

SCIENCE, 1985, 230 (4724) :456-458

[4]

ANDERSEN RA, 1990, J NEUROSCI, V10, P1176

[5]

Astafiev SV, 2003, J NEUROSCI, V23, P4689

[6] Cortical Connections of Parietal Field PEc in the Macaque: Linking Vision and Somatic Sensation for the Control of Limb Action [J].

Bakola, Sophia ;

Gamberini, Michela ;

Passarelli, Lauretta ;

Fattori, Patrizia ;

Galletti, Claudio .

CEREBRAL CORTEX, 2010, 20 (11) :2592-2604

[7] Reach plans in eye-centered coordinates [J].

Batista, AP ;

Buneo, CA ;

Snyder, LH ;

Andersen, RA .

SCIENCE, 1999, 285 (5425) :257-260

[8] Impairment of Online Control of Hand and Eye Movements in a Monkey Model of Optic Ataxia [J].

Battaglia-Mayer, Alexandra ;

Ferrari-Toniolo, Simone ;

Visco-Comandini, Federica ;

Archambault, Philippe S. ;

Saberi-Moghadam, Sohrab ;

Caminiti, Roberto .

CEREBRAL CORTEX, 2013, 23 (11) :2644-2656

[9] Effects of lesions to area V6A in monkeys [J].

Battaglini, PP ;

Muzur, A ;

Galletti, C ;

Skrap, M ;

Brovelli, A ;

Fattori, P .

EXPERIMENTAL BRAIN RESEARCH, 2002, 144 (03) :419-422

[10] Spatial and Effector Processing in the Human Parietofrontal Network for Reaches and Saccades [J].

Beurze, S. M. ;

de Lange, F. P. ;

Toni, I. ;

Medendorp, W. P. .

JOURNAL OF NEUROPHYSIOLOGY, 2009, 101 (06) :3053-3062

← 1 2 3 4 5 6 7 8 9 10 →