Type I and II Endometrial Cancers: Have They Different Risk Factors?

被引：743

作者：

Setiawan, Veronica Wendy ^{[1
]}

Yang, Hannah P. ^{[5
]}

Pike, Malcolm C. ^{[1
,6
]}

McCann, Susan E. ^{[7
]}

Yu, Herbert ^{[10
]}

Xiang, Yong-Bing ^{[11
]}

Wolk, Alicja ^{[12
]}

Wentzensen, Nicolas ^{[5
]}

Weiss, Noel S. ^{[13
]}

Webb, Penelope M. ^{[15
]}

van den Brandt, Piet A. ^{[16
]}

van de Vijver, Koen ^{[16
]}

Thompson, Pamela J. ^{[10
]}

Strom, Brian L. ^{[17
]}

Spurdle, Amanda B. ^{[15
]}

Soslow, Robert A. ^{[6
]}

Shu, Xiao-ou ^{[18
]}

Schairer, Catherine ^{[5
]}

Sacerdote, Carlotta ^{[19
]}

Rohan, Thomas E. ^{[9
]}

Robien, Kim ^{[20
]}

Risch, Harvey A. ^{[21
]}

Ricceri, Fulvio ^{[19
]}

Rebbeck, Timothy R. ^{[17
]}

Rastogi, Radhai ^{[6
]}

Prescott, Jennifer ^{[22
,23
]}

Polidoro, Silvia ^{[19
]}

Park, Yikyung ^{[5
]}

Olson, Sara H. ^{[6
]}

Moysich, Kirsten B. ^{[7
]}

Miller, Anthony B. ^{[26
]}

McCullough, Marjorie L. ^{[29
]}

Matsuno, Rayna K. ^{[10
]}

Magliocco, Anthony M. ^{[30
]}

Lurie, Galina ^{[10
]}

Lu, Lingeng ^{[21
]}

Lissowska, Jolanta ^{[31
,32
]}

Liang, Xiaolin ^{[6
]}

Lacey, James V., Jr. ^{[2
]}

Kolonel, Laurence N. ^{[10
]}

Henderson, Brian E. ^{[1
]}

Hankinson, Susan E. ^{[22
,23
,25
]}

Hakansson, Niclas ^{[12
]}

Goodman, Marc T. ^{[10
]}

Gaudet, Mia M. ^{[29
]}

Garcia-Closas, Montserrat ^{[33
]}

Friedenreich, Christine M. ^{[27
]}

Freudenheim, Jo L. ^{[8
]}

Doherty, Jennifer ^{[34
]}

De Vivo, Immaculata ^{[22
,23
,24
]}

机构：

[1] Univ So Calif, Los Angeles, CA 90033 USA

[2] City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USA

[3] Univ Calif Irvine, Irvine, CA USA

[4] Canc Prevent Inst Calif, Fremont, CA USA

[5] NCI, Bethesda, MD 20892 USA

[6] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[7] Roswell Pk Canc Inst, Buffalo, NY USA

[8] SUNY Buffalo, Buffalo, NY 14260 USA

[9] Albert Einstein Coll Med, Bronx, NY 10467 USA

[10] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA

[11] Shanghai Canc Inst, Shanghai, Peoples R China

[12] Karolinska Inst, Stockholm, Sweden

[13] Univ Washington, Seattle, WA 98195 USA

[14] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[15] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

[16] Maastricht Univ, Maastricht, Netherlands

[17] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

[18] Vanderbilt Univ, Med Ctr, Nashville, TN USA

[19] Human Genet Fdn, Turin, Italy

[20] Univ Minnesota, Minneapolis, MN USA

[21] Yale Univ, Sch Publ Hlth, New Haven, CT USA

[22] Brigham & Womens Hosp, Boston, MA 02115 USA

[23] Harvard Univ, Med Sch, Cambridge, MA 02138 USA

[24] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

[25] Univ Massachusetts, Amherst, MA 01003 USA

[26] Univ Toronto, Toronto, ON, Canada

[27] Alberta Hlth Serv Canc Care, Calgary, AB, Canada

[28] Univ Alberta, Edmonton, AB, Canada

[29] Amer Canc Soc, Atlanta, GA 30329 USA

[30] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[31] M Sklodowska Curie Mem Canc Ctr, Warsaw, Poland

[32] Inst Oncol, Warsaw, Poland

[33] Inst Canc Res, Sutton, Surrey, England

[34] Dartmouth Coll, Hanover, NH 03755 USA

[35] Univ New Mexico, Albuquerque, NM 87131 USA

[36] Mayo Clin, Rochester, MN USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2013年 / 31卷 / 20期

基金：

瑞典研究理事会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会; 美国国家卫生研究院;

关键词：

CARCINOMA; OBESITY; WOMEN; CARCINOGENESIS; METAANALYSIS; SMOKING; HEALTH;

D O I：

10.1200/JCO.2012.48.2596

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Purpose Endometrial cancers have long been divided into estrogen-dependent type I and the less common clinically aggressive estrogen-independent type II. Little is known about risk factors for type II tumors because most studies lack sufficient cases to study these much less common tumors separately. We examined whether so-called classical endometrial cancer risk factors also influence the risk of type II tumors. Patients and Methods Individual-level data from 10 cohort and 14 case-control studies from the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 14,069 endometrial cancer cases and 35,312 controls were included. We classified endometrioid (n = 7,246), adenocarcinoma not otherwise specified (n = 4,830), and adenocarcinoma with squamous differentiation (n = 777) as type I tumors and serous (n = 508) and mixed cell (n = 346) as type II tumors. Results Parity, oral contraceptive use, cigarette smoking, age at menarche, and diabetes were associated with type I and type II tumors to similar extents. Body mass index, however, had a greater effect on type I tumors than on type II tumors: odds ratio (OR) per 2 kg/m(2) increase was 1.20 (95% CI, 1.19 to 1.21) for type I and 1.12 (95% CI, 1.09 to 1.14) for type II tumors (P-heterogeneity < .0001). Risk factor patterns for high-grade endometrioid tumors and type II tumors were similar. Conclusion The results of this pooled analysis suggest that the two endometrial cancer types share many common etiologic factors. The etiology of type II tumors may, therefore, not be completely estrogen independent, as previously believed. (C) 2013 by American Society of Clinical Oncology

引用

页码：2607 / +

页数：14

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