Brain-derived neurotrophic factor serum concentrations in depressive patients during vagus nerve stimulation and repetitive transcranial magnetic stimulation

被引：58

作者：

Lang, Undine E.

Bajbouj, Malek

Gallinat, Juergen

Hellweg, Rainer

机构：

[1] Charite Univ Med Berlin, Dept Psychiat, Berlin, Germany

[2] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

来源：

PSYCHOPHARMACOLOGY | 2006年 / 187卷 / 01期

关键词：

brain-derived neurotrophic factor (BDNF); major depression; vagus nerve stimulation (VNS); transcranial magnetic stimulation (rTMS);

D O I：

10.1007/s00213-006-0399-y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

background: Vagus nerve stimulation (VNS) and repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex are brain stimulation techniques used as therapeutic interventions in major depression. Methods: In this study, we report the impact of these stimulation techniques on serum concentrations of brain-derived neurotrophic factor (BDNF) in treatment-resistant patients with a diagnosis of major depression. Results: We found no changes of BDNF serum concentrations and no association of neurotrophin concentrations in serum with clinical parameters in our sample. Conclusions: Our preliminary results suggest that brain stimulation techniques-in contrast to several antidepressant medications-do not change BDNF serum concentrations.

引用

页码：56 / 59

页数：4

共 20 条

[1] The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study [J].