Evaluation of Meniscal Mechanics and Proteoglycan Content in a Modified Anterior Cruciate Ligament Transection Model

被引：30

作者：

Fischenich, Kristine M. ^{[1
]}

Coatney, Garrett A. ^{[1
]}

Haverkamp, John H. ^{[1
]}

Button, Keith D. ^{[2
]}

DeCamp, Charlie ^{[3
]}

Haut, Roger C. ^{[2
]}

Donahue, Tammy L. Haut ^{[1
]}

机构：

[1] Colorado State Univ, Dept Mech Engn, Ft Collins, CO 80523 USA

[2] Michigan State Univ, Orthopaed Biomech Labs, Coll Osteopath Med, E Lansing, MI 48824 USA

[3] Michigan State Univ, Coll Vet, E Lansing, MI 48824 USA

来源：

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | 2014年 / 136卷 / 07期

基金：

美国国家卫生研究院;

关键词：

RABBIT MENISCECTOMY MODEL; SUBCHONDRAL BONE CHANGES; ARTICULAR-CARTILAGE; MEDIAL MENISCUS; DEFICIENT KNEE; EXPERIMENTAL OSTEOARTHRITIS; IN-VIVO; NATURAL OSTEOARTHRITIS; BIOCHEMICAL CHANGES; LAPINE MENISCI;

D O I：

10.1115/1.4027468

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

Post-traumatic osteoarthritis (PTOA) develops as a result of traumatic loading that causes tears of the soft tissues in the knee. A modified transection model, where the anterior cruciate ligament (ACL) and both menisci were transected, was used on skeletally mature Flemish Giant rabbits. Gross morphological assessments, elastic moduli, and glycosaminoglycan (GAG) coverage of the menisci were determined to quantify the amount of tissue damage 12 weeks post injury. This study is one of the first to monitor meniscal changes after inducing combined meniscal and ACL transections. A decrease in elastic moduli as well as a decrease in GAG coverage was seen.

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