Cytotoxic triterpenoides from Alismatis Rhizoma

被引：45

作者：

Lee, S

Kho, Y

Min, B

Kim, J

Na, M

Kang, S

Maeng, H

Bae, K ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea

[3] Joongbu Univ, Dept Life Sci, Keumsan Chungnam 312702, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2001年 / 24卷 / 06期

关键词：

Alismatis Rhizoma; alisol B; cytotoxicity;

D O I：

10.1007/BF02975158

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four prostane-type triterpenes were isolated from a methanol extract of Alismatis Rhizoma by bioassay-guided isolation using in vitro cytotoxic assay. The compounds were identified as alisol B 23-acetate (1), alisol C 23-acetate (2), alisol B (3), alisol A 24-acetate (4) by spectroscopic methods. Amongst the compounds, alisol B (3) showed significant cytotoxicity against SK-OV3, B16-F10, and HT1080 cancer cell lines with ED50 values of 7.5, 7.5, 4.9 mug/ml, respectively.

引用

页码：524 / 526

页数：3

共 8 条

[1]

FUKUYAMA Y, 1998, PLANTA MED, V54, P445

[2]

MURATA T, 1970, CHEM PHARM BULL, V18, P1369

[3] NEW COLORIMETRIC CYTOTOXICITY ASSAY FOR ANTICANCER-DRUG SCREENING [J].

SKEHAN, P ;

STORENG, R ;

SCUDIERO, D ;

MONKS, A ;

MCMAHON, J ;

VISTICA, D ;

WARREN, JT ;

BOKESCH, H ;

KENNEY, S ;

BOYD, MR .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (13) :1107-1112

[4] A KAURANE DERIVATIVE ISOLATED FROM ALISMA-ORIENTALE [J].

YAMAGUCHI, K ;

IDA, Y ;

SATOH, Y ;

NAKAJIMA, Y ;

SHOJI, J .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1994, 50 :738-740

[5]

Yamaguchi T., 1995, Patent No. [JP 07173188, 07173188]

[6]

YAMAHARA, 1989, PHYTOTHER RES, V3, P57

[7]

YOSHIKAWA M, 1994, CHEM PHARM BULL, V42, P1813, DOI 10.1248/cpb.42.1813

[8]

YOSHIKAWA M, 1992, CHEM PHARM BULL, V40, P2582, DOI 10.1248/cpb.40.2582

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