Importance of asymmetrical dimethylarginine in cardiovascular risk

被引：87

作者：

Vallance, P ^{[1
]}

机构：

[1] UCL, Dept Med, Ctr Clin Pharmacol & Therapeut, London WC1E 6JJ, England

来源：

LANCET | 2001年 / 358卷 / 9299期

关键词：

D O I：

10.1016/S0140-6736(01)07229-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：2096 / 2097

页数：2

共 8 条

[1] ACCUMULATION OF ENDOGENOUS INHIBITORS FOR NITRIC-OXIDE SYNTHESIS AND DECREASED CONTENT OF L-ARGININE IN REGENERATED ENDOTHELIAL-CELLS [J].

AZUMA, H ;

SATO, J ;

HAMASAKI, H ;

SUGIMOTO, A ;

ISOTANI, E ;

OBAYASHI, S .

BRITISH JOURNAL OF PHARMACOLOGY, 1995, 115 (06) :1001-1004

[2] Does ADMA cause endothelial dysfunction? [J].

Cooke, JP .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (09) :2032-2037

[3] The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide [J].

Furchgott, RF .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 276 (14) :1186-1188

[4] Biological significance of endogenous methylarginines that inhibit nitric oxide synthases [J].

Leiper, J ;

Vallance, P .

CARDIOVASCULAR RESEARCH, 1999, 43 (03) :542-548

[5] Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases [J].

Leiper, JM ;

Maria, JS ;

Chubb, A ;

MacAllister, RJ ;

Charles, IG ;

Whitley, GSJ ;

Vallance, P .

BIOCHEMICAL JOURNAL, 1999, 343 :209-214

[6] Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase [J].

Murray-Rust, J ;

Leiper, J ;

McAlister, M ;

Phelan, J ;

Tilley, S ;

Maria, JS ;

Vallance, P ;

McDonald, N .

NATURE STRUCTURAL BIOLOGY, 2001, 8 (08) :679-683

[7] Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney [J].

Tojo, A ;

Welch, WJ ;

Bremer, V ;

Kimoto, M ;

Kimura, K ;

Omata, M ;

Ogawa, T ;

Vallance, P ;

Wilcox, CS .

KIDNEY INTERNATIONAL, 1997, 52 (06) :1593-1601

[8]

VALLANCE P, 1992, LANCET, V339, P572

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