Molecular pathogenesis of pancreatic ductal adenocarcinoma and clinical implications

被引：23

作者：

Magee, CJ ^{[1
]}

Greenhalf, W ^{[1
]}

Howes, N ^{[1
]}

Ghaneh, P ^{[1
]}

Neoptolemos, JP ^{[1
]}

机构：

[1] Royal Liverpool Univ Hosp, Dept Surg, Liverpool L69 3GA, Merseyside, England

来源：

SURGICAL ONCOLOGY-OXFORD | 2001年 / 10卷 / 1-2期

关键词：

pancreatic cancer; hereditary pancreatitis; pathogenesis; screening; treatment;

D O I：

10.1016/S0960-7404(01)00016-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is a significant cause of cancer death worldwide. PDAC is also one of the best-studied cancers with regard to molecular pathogenesis. The chief risk factors associated with PDAC are smoking and pancreatitis, in addition genetic predisposition seems to play a major role. This genetic predisposition may in some cases be indirect, for example via the elevated risk of pancreatitis seen in patients with hereditary pancreatitis (HP). The elucidation of the molecular causes of PDAC has enabled the provision of secondary screening for PDAC in conditions such as HP. This review is concerned with the molecular pathogenesis of PDAC and the application of this basic scientific understanding into state-of-the-art clinical practice. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1 / 23

页数：23

共 187 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2]

ALLEMA JH, 1995, CANCER, V75, P2069, DOI 10.1002/1097-0142(19950415)75:8<2069::AID-CNCR2820750807>3.0.CO

[3]

2-7

[4] MOST HUMAN CARCINOMAS OF THE EXOCRINE PANCREAS CONTAIN MUTANT C-K-RAS GENES [J].

ALMOGUERA, C ;

SHIBATA, D ;

FORRESTER, K ;

MARTIN, J ;

ARNHEIM, N ;

PERUCHO, M .

CELL, 1988, 53 (04) :549-554

[5]

[Anonymous], 1992, Cancer incidence in five continents

[6]

[Anonymous], 1999, Cancer survival trends in England and Wales, 1971-1995: deprivation and NHS region

[7]

AOKI K, 1995, CANCER RES, V55, P3810

[8] Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas:: Evidence for multistep carcinogenesis [J].

Apple, SK ;

Hecht, JR ;

Lewin, DN ;

Jahromi, SA ;

Grody, WW ;

Nieberg, RK .

HUMAN PATHOLOGY, 1999, 30 (02) :123-129

[9] Role of the IκB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells [J].

Arsura, M ;

Mercurio, F ;

Oliver, AL ;

Thorgeirsson, SS ;

Sonenshein, GE .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (15) :5381-5391

[10] Apoptosis control by death and decoy receptors [J].

Ashkenazi, A ;

Dixit, VM .

CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (02) :255-260

← 1 2 3 4 5 6 7 8 9 10 →