The use of immunohistochemistry for evaluating the liver

被引:12
作者
Hall, WC
Rojko, JL
机构
关键词
review; hepatocyte; sinusoidal cells; Kupffer cell; perisinusoidal cell; endothelium; integrin; cell receptors; cytokine; chemikines; cell proliferation; apoptosis; neoplasia;
D O I
10.1177/019262339602400103
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Immunohistochemistry has been utilized in recent years primarily for diagnosis of infectious diseases of the liver, especially in humans. The utility of immunohistochemistry has extended to experimental and toxicologic pathology in a variety of areas: identification of cell phenotype, cell receptors, cytokine and chemikine production, and functional cell changes such as enzyme induction. In addition, markers for experimental carcinogenesis studies are detectable by immunohistochemical changes as well as novel antigen induction such as placental glutathione-S-transferase, oncofetal proteins, oncogene products, and typing of neoplasms. Immunohistochemistry is also used to detect the origin and function of various cell types in developmental and toxicity studies. Careful use of immunohistochemical procedures in conjunction with routine pathology and molecular techniques enhance the ability of the toxicologic pathologist to diagnose unique conditions and to understand mechanisms of lesion development.
引用
收藏
页码:4 / 12
页数:9
相关论文
共 107 条
  • [1] DIFFERENTIAL REGULATION OF GLUTATHIONE-S-TRANSFERASES IN CULTURED-HEPATOCYTES
    ABRAMOVITZ, M
    ISHIGAKI, S
    LISTOWSKY, I
    [J]. HEPATOLOGY, 1989, 9 (02) : 235 - 239
  • [2] ANDERSON LM, 1987, CANCER RES, V47, P6079
  • [3] AN IMPROVED METHOD FOR THE INHIBITION OF ENDOGENOUS PEROXIDASE NONDELETERIOUS TO LYMPHOCYTE SURFACE-MARKERS - APPLICATION TO IMMUNOPEROXIDASE STUDIES ON EOSINOPHIL-RICH TISSUE PREPARATIONS
    ANDREW, SM
    JASANI, B
    [J]. HISTOCHEMICAL JOURNAL, 1987, 19 (08): : 426 - 430
  • [4] THE RESISTANT HEPATOCYTE MODEL OF CARCINOGENESIS IN THE RAT - THE APPARENT INDEPENDENT DEVELOPMENT OF OVAL CELL-PROLIFERATION AND EARLY NODULES
    ANILKUMAR, TV
    GOLDING, M
    EDWARDS, RJ
    LALANI, EN
    SARRAF, CE
    ALISON, MR
    [J]. CARCINOGENESIS, 1995, 16 (04) : 845 - 853
  • [5] DESMIN AND ACTIN IN THE IDENTIFICATION OF ITO CELLS AND IN MONITORING THEIR EVOLUTION TO MYOFIBROBLASTS IN EXPERIMENTAL LIVER FIBROSIS
    BALLARDINI, G
    FALLANI, M
    BIAGINI, G
    BIANCHI, FB
    PISI, E
    [J]. VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1988, 56 (01) : 45 - 49
  • [6] BANNASCH P, 1981, LAB INVEST, V44, P252
  • [7] BARCLAY AN, 1993, LEUKOCYTE ANTIGEN FA
  • [8] NERVES AND PERISINUSOIDAL CELLS IN HUMAN-LIVER
    BIOULACSAGE, P
    LAFON, ME
    SARIC, J
    BALABAUD, C
    [J]. JOURNAL OF HEPATOLOGY, 1990, 10 (01) : 105 - 112
  • [9] BLOOMHOFF R, 1991, FASEB J, V5, P271
  • [10] BOGERS WMJM, 1991, CLIN EXP IMMUNOL, V85, P128