Sleep and serotonin: An unfinished story

被引：97

作者：

Jouvet, M ^{[1
]}

机构：

[1] Univ Lyon 1, F-69373 Lyon 08, France

来源：

NEUROPSYCHOPHARMACOLOGY | 1999年 / 21卷 / 02期

关键词：

5-hydroxytryptamine; sleep; raphe system; preoptic region;

D O I：

10.1038/sj.npp.1395333

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonin (5-HT) was first believed to be a true neuromodulator of sleep because the destruction of 5-HT neurons of the raphe system, or the inhibition of 5-HT synthesis with p-chlorophenylalanine induced a severe insomnia which could be reversed by restoring 5-HT synthesis. However the demonstration that the electrical activity of 5-HT perikarya and the release of 5-HT are increased during waking and decreased during sleep was in direct contradiction to this hypothesis. More recent experiments suggest that the release of 5-HT during waking may initiate a cascade of genomic events in some hypnogenic neurons located in the preoptic area. Thus, when 5-HT is released during waking, it lends to an homeostatic regulation of slow-wave sleep. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

引用

页码：S24 / S27

页数：4

共 21 条

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