EGFR mutations and molecularly targeted therapy:: a new era in the treatment of lung cancer

被引:15
作者
Dowell, JE
Minna, JD
机构
[1] Univ Texas, SW Med Ctr, Hamon Ctr Therapeut Oncol, Dallas, TX 75390 USA
[2] Dallas VA Med Ctr, Dallas, TX USA
[3] Univ Texas, SW Med Ctr, Ctr Canc Genet, Dallas, TX USA
[4] Univ Texas, SW Med Ctr, NCI Special Program Res Excellence, Dallas, TX USA
来源
NATURE CLINICAL PRACTICE ONCOLOGY | 2006年 / 3卷 / 04期
关键词
D O I
10.1038/ncponc0476
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:170 / 171
页数:2
相关论文
共 10 条
[1]   Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer [J].
Cappuzzo, F ;
Hirsch, FR ;
Rossi, E ;
Bartolini, S ;
Ceresoli, GL ;
Bemis, L ;
Haney, J ;
Witta, S ;
Danenberg, K ;
Domenichini, I ;
Ludovini, V ;
Magrini, E ;
Gregorc, V ;
Doglioni, C ;
Sidoni, A ;
Tonato, M ;
Franklin, WA ;
Crino, L ;
Bunn, PA ;
Varella-Garcia, M .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (09) :643-655
[2]   The impact of epidermal-growth-factor-receptor mutations in response to lung-cancer therapy [J].
Dowell, Jonathan E. ;
Minna, John D. .
NATURE CLINICAL PRACTICE ONCOLOGY, 2004, 1 (01) :2-3
[3]   Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer [J].
Fukuoka, M ;
Yano, S ;
Giaccone, G ;
Tamura, T ;
Nakagawa, K ;
Douillard, JY ;
Nishiwaki, Y ;
Vansteenkiste, J ;
Kudoh, S ;
Rischin, D ;
Eek, R ;
Horai, T ;
Noda, K ;
Takata, I ;
Smit, E ;
Averbuch, S ;
Macleod, A ;
Feyereislova, A ;
Dong, RP ;
Baselga, J .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (12) :2237-2246
[4]  
HIRSCH FR, 2005, P AACR NCI EORTC C M, P124
[5]   Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer - A randomized trial [J].
Kris, MG ;
Natale, RB ;
Herbst, RS ;
Lynch, TJ ;
Prager, D ;
Belani, CP ;
Schiller, JH ;
Kelly, K ;
Spiridonidis, H ;
Sandler, A ;
Albain, KS ;
Cella, D ;
Wolf, MK ;
Averbuch, SD ;
Ochs, JJ ;
Kay, AC .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (16) :2149-2158
[6]   Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [J].
Lynch, TJ ;
Bell, DW ;
Sordella, R ;
Gurubhagavatula, S ;
Okimoto, RA ;
Brannigan, BW ;
Harris, PL ;
Haserlat, SM ;
Supko, JG ;
Haluska, FG ;
Louis, DN ;
Christiani, DC ;
Settleman, J ;
Haber, DA .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (21) :2129-2139
[7]   EGFR mutations in lung cancer:: Correlation with clinical response to gefitinib therapy [J].
Paez, JG ;
Jänne, PA ;
Lee, JC ;
Tracy, S ;
Greulich, H ;
Gabriel, S ;
Herman, P ;
Kaye, FJ ;
Lindeman, N ;
Boggon, TJ ;
Naoki, K ;
Sasaki, H ;
Fujii, Y ;
Eck, MJ ;
Sellers, WR ;
Johnson, BE ;
Meyerson, M .
SCIENCE, 2004, 304 (5676) :1497-1500
[8]   Erlotinib in previously treated non-small-cell lung cancer [J].
Shepherd, FA ;
Pereira, JR ;
Ciuleanu, T ;
Tan, EH ;
Hirsh, V ;
Thongprasert, S ;
Campos, D ;
Maoleekoonpiroj, S ;
Smylie, M ;
Martins, R ;
van Kooten, M ;
Dediu, M ;
Findlay, B ;
Tu, DS ;
Johnston, D ;
Bezjak, A ;
Clark, G ;
Santabárbara, P ;
Seymour, L .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (02) :123-132
[9]   Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer) [J].
Thatcher, N ;
Chang, A ;
Parikh, P ;
Pereira, JR ;
Ciuleanu, T ;
von Pawel, J ;
Thongprasert, S ;
Tan, EH ;
Pemberton, K ;
Archer, V ;
Carroll, K .
LANCET, 2005, 366 (9496) :1527-1537
[10]   Erlotinib in lung cancer - Molecular and clinical predictors of outcome [J].
Tsao, MS ;
Sakurada, A ;
Cutz, JC ;
Zhu, CQ ;
Kamel-Reid, S ;
Squire, J ;
Lorimer, I ;
Zhang, T ;
Liu, N ;
Daneshmand, M ;
Marrano, P ;
Santos, GD ;
Lagarde, A ;
Richardson, F ;
Seymour, L ;
Whitehead, M ;
Ding, KY ;
Pater, J ;
Shepherd, FA .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (02) :133-144