Expression of Alternaria solani PKSF generates a set of complex reduced-type polyketides with different carbon-lengths and cyclization

被引：31

作者：

Kasahara, Ken

Fujii, Isao

Oikawa, Hideaki

Ebizuka, Yutaka

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Hokkaido Univ, Grad Sch Sci, Sapporo, Hokkaido 0600810, Japan

来源：

CHEMBIOCHEM | 2006年 / 7卷 / 06期

关键词：

Alternaria solani; aslaniol; aslanipyrone; biosynthesis; iterative type I polyketide synthase; polyketides;

D O I：

10.1002/cbic.200600034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An iterative type I polyketide synthase gene, named pksF, has been cloned from Alternaria solani. The Aspergillus oryzae pksF expression transformant produced two new polyene products, named aslanipyrone (1) and aslaniol (2), and at least nine other polyene compounds. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：920 / 924

页数：5

共 21 条

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[Anonymous], [No title captured]

[2]

[Anonymous], 2004, ADV FUNGAL BIOTECHNO

[3] An iterative type I polyketide synthase PKSN catalyzes synthesis of the decaketide alternapyrone with regio-specific octa-methylation [J].