Protein folding:: Is hierarchical versus nonhierarchical a productive issue?

被引：4

作者：

Fernández, A ^{[1
]}

机构：

[1] Univ Chicago, Inst Biophys Dynam, Cummings Life Sci Ctr, Chicago, IL 60637 USA

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 2002年 / 19卷 / 05期

关键词：

D O I：

10.1080/07391102.2002.10506781

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A coarse-grained simulation accessing relevant folding timescales for beta-lactoglobulin was corroborated experimentally and reveals a dynamic role for normative structures dictated by local propensity vis-a-vis the large-scale context. This picture prompts us to shift focus, leaving aside the hierarchical vs. nonhierarchical controversy.

引用

页码：735 / 737

页数：3

共 10 条

[1] Is protein folding hierarchic? II. Folding intermediates and transition states
Baldwin, RL
Rose, GD
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (02) : 77 - 83
[2] Folding consensus?
Baldwin, RL
[J]. NATURE STRUCTURAL BIOLOGY, 2001, 8 (02) : 92 - 94
[3] Is protein folding hierarchic? I. Local structure and peptide folding
Baldwin, RL
Rose, GD
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (01) : 26 - 33
[4] Conformation-dependent environments in folding proteins
Fernández, A
[J]. JOURNAL OF CHEMICAL PHYSICS, 2001, 114 (05) : 2489 - 2502
[5] Topology to geometry in protein folding:: β-Lactoglobulin
Fernández, A
Colubri, A
Berry, RS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (26) : 14062 - 14066
[6] Non-native alpha-helical intermediate in the refolding of beta-lactoglobulin, a predominantly beta-sheet protein
Hamada, D
Segawa, S
Goto, Y
[J]. NATURE STRUCTURAL BIOLOGY, 1996, 3 (10): : 868 - 873
[7] KUWATA, 1996, NATURE STRUCT BIOL, V8, P151
[8] Elucidating the folding problem of α-helices:: Local motifs, long-range electrostatics, ionic-strength dependence and prediction of NMR parameters
Lacroix, E
Viguera, AR
Serrano, L
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1998, 284 (01) : 173 - 191
[9] Energetics of protein structure
Makhatadze, GI
Privalov, PL
[J]. ADVANCES IN PROTEIN CHEMISTRY, VOL 47, 1995, 47 : 307 - 425
[10] NMR structure of the 35-residue villin headpiece subdomain
McKnight, CJ
Matsudaira, PT
Kim, PS
[J]. NATURE STRUCTURAL BIOLOGY, 1997, 4 (03) : 180 - 184

← 1 →