Growth hormone, insulin-like growth factor-1 and the aging brain

被引：165

作者：

Ashpole, Nicole M. ^{[1
]}

Sanders, Jessica E. ^{[1
]}

Hodges, Erik L. ^{[1
]}

Yan, Han ^{[1
]}

Sonntag, William E. ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Donald W Reynolds Dept Geriatr Med, Reynolds Oklahoma Ctr Aging, Oklahoma City, OK 73104 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2015年 / 68卷

关键词：

Aging; Brain; Neuroendocrine; IGF-1; GH; EXCITATORY SYNAPTIC-TRANSMISSION; RECEPTOR GENE-EXPRESSION; LONG-TERM POTENTIATION; SOMATOMEDIN-C LEVELS; RAT HIPPOCAMPUS; NMDA RECEPTOR; LIFE-SPAN; MESSENGER-RNA; IGF-I; HYPOPHYSECTOMIZED RATS;

D O I：

10.1016/j.exger.2014.10.002

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Growth hormone (GH) and insulin-like growth factor (IGF)-1 regulate the development and function of cells throughout the body. Several clinical diseases that result in a decline in physical and mental functions are marked by mutations that disrupt GH or IGF-1 signaling. During the lifespan there is a robust decrease in both GH and IGF-1. Because GH and IGF-1 are master regulators of cellular function, impaired GH and IGF-1 signaling in aging/disease states leads to significant alterations in tissue structure and function, especially within the brain. This review is intended to highlight the effects of the GH and IGF-1 on neuronal structure, function, and plasticity. Furthermore, we address several potential mechanisms through which the age-related reductions in GH and IGF-1 affect cognition. Together, the studies reviewed here highlight the importance of maintaining GH and IGF-1 signaling in order to sustain proper brain function throughout the lifespan. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：76 / 81

页数：6

共 87 条

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