Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis

被引：46

作者：

Alvarez-Baron, Elena ^{[1
,2
]}

Bien, Christian G. ^{[2
]}

Schramm, Johannes ^{[3
]}

Elger, Christian E. ^{[2
]}

Becker, Albert J. ^{[1
]}

Schoch, Susanne ^{[1
,2
]}

机构：

[1] Univ Bonn, Sch Med, Dept Neuropathol, D-53105 Bonn, Germany

[2] Univ Bonn, Sch Med, Dept Epileptol, D-53105 Bonn, Germany

[3] Univ Bonn, Sch Med, Dept Neurosurg, D-53105 Bonn, Germany

来源：

EPILEPSY RESEARCH | 2008年 / 80卷 / 01期

关键词：

epilepsy; autoimmune reactivity; synapse; plasma cells; B-lymphocytes; Rasmussen encephalitis;

D O I：

10.1016/j.eplepsyres.2008.03.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Rasmussen encephalitis (RE) is a rare form of severe unihemispheric epilepsy established to be an autoimmune disease. Here we demonstrate the presence of autoantibodies against Munc18-1 in 20% of patients collective with biopsy-proven RE. Intriguingly, brain biopsy specimens of these patients showed a striking perivascular accentuated infiltration of B-lymphocytes and plasma cells, suggesting a subgroup of RE patients harboring Munc18-1 antibodies and concomitant B- and plasma cell infiltration. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：93 / 97

页数：5

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