Teratogenesis of holoprosencephaly

被引：124

作者：

Cohen, MM ^{[1
]}

Shiota, K

机构：

[1] Dalhousie Univ, Hlth Serv Adm, Dept Oral & Maxillofacial Surg, Halifax, NS B3H 3J5, Canada

[2] Dalhousie Univ, Hlth Serv Adm, Dept Pediat, Halifax, NS, Canada

[3] Dalhousie Univ, Hlth Serv Adm, Dept Community Hlth & Epidemiol, Halifax, NS, Canada

[4] Dalhousie Univ, Dept Sociol & Social Anthropol, Halifax, NS, Canada

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 2002年 / 109卷 / 01期

关键词：

diabetic embryopathy; ethyl alcohol; retinoic acid; sonic hedgehog; cholesterol; hyperglycemia; alcohol dehydrogenase; acetaldehyde; neural crest; Smith-Lemli-Opitz syndrome; DHCR7; AY9944; BM15.766; cyclopamine; jervine; sterol adduct; sterol sensing domain;

D O I：

10.1002/ajmg.10258

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Teratogenic causes of holoprosencephaly are critically assessed. A brief general review of holoprosencephaly is followed by four tables summarizing etiologic factors. Subjects evaluated here include: 1) maternal diabetes; 2) ethyl alcohol; 3) retinoic acid; 4) mutated genes and teratogens involving the sonic hedgehog signaling network and cholesterol biosynthesis; and 5) cholesterol trafficking, sterol adducts, target tissue response, and sterol sensing domain. (C) 2002 Wiley-Liss, Inc.

引用

页码：1 / 15

页数：15

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