Laser-activated adhesive films for sutureless median nerve anastomosis

被引：30

作者：

Barton, Mathew ^{[1
]}

Morley, John W. ^{[1
]}

Stoodley, Marcus A. ^{[3
]}

Ng, Kheng-Seong ^{[1
]}

Piller, Sabine C. ^{[2
]}

Duong, Hong ^{[3
]}

Mawad, Damia ^{[4
,5
,6
]}

Mahns, David A. ^{[1
]}

Lauto, Antonio ^{[1
,4
]}

机构：

[1] Univ Western Sydney, Sch Med, Penrith, NSW 2751, Australia

[2] Univ Western Sydney, Sch Sci & Hlth, Penrith, NSW 2751, Australia

[3] Macquarie Univ, Australian Sch Adv Med, N Ryde, NSW 2109, Australia

[4] Univ Western Sydney, MARCS Inst, Bioelect & Neurosci BENS Res Grp, Penrith, NSW 2751, Australia

[5] Univ London Imperial Coll Sci Technol & Med, Dept Mat, Dept Bioengn, London SW7 2AZ, England

[6] Univ London Imperial Coll Sci Technol & Med, Inst Biomed Engn, London SW7 2AZ, England

来源：

JOURNAL OF BIOPHOTONICS | 2013年 / 6卷 / 11-12期

关键词：

Photochemical tissue bonding; Rose Bengal; peripheral nerve repair; chitosan; CHITOSAN ADHESIVE; IN-VITRO; TISSUE ADHESIVES; ROSE-BENGAL; REPAIR; CONDUITS; COLLAGEN; HYDROGELS; SCAFFOLD; GLYCOL;

D O I：

10.1002/jbio.201300054

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

A novel chitosan adhesive film that incorporates the dye Rose Bengal' (RB) was used in conjunction with a green laser to repair transected rat median nerves in vivo. Histology and electrophysiological recording assessed the impact of the laser-adhesive technique on nerves. One week post-operatively, the sham-control group (laser-adhesive technique applied on un-transected nerves) conserved the average number and size of myelinated fibres in comparison to its contralateral side and electrophysiological recordings demonstrated no significant difference with un-operated nerves. Twelve weeks after the laser-adhesive anastomoses, nerves were in continuity with regenerated axons that crossed the anastomotic site. ((c) 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

引用

页码：938 / 949

页数：12

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