CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)

被引:257
作者
Nagata, K
Hirai, H
Tanaka, K
Ogawa, K
Aso, T
Sugamura, K
Nakamura, M
Takano, S
机构
[1] BioMed Labs Inc, Ctr Res & Dev, Kawagoe, Saitama 3501101, Japan
[2] Tohoku Univ, Sch Med, Dept Microbiol & Immunol, Aoba Ku, Sendai, Miyagi 9808575, Japan
[3] Tokyo Med & Dent Univ, Sch Med, Dept Obstet & Gynecol, Bunkyo Ku, Tokyo 1138510, Japan
[4] Tokyo Med & Dent Univ, Human Gene Sci Ctr, Bunkyo Ku, Tokyo 1138510, Japan
关键词
orphan receptor; Th2; basophil; eosinophil; ligand producer; mast cell;
D O I
10.1016/S0014-5793(99)01251-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have recently cloned a putative chemoattractant receptor, named CRTH2, which is preferentially expressed on human T-helper- (Th) 2 but not Th1 cells. In this study, we demonstrated that CRTH2 is also highly expressed on peripheral blood basophils and eosinophils. Our search for a CRTH2 ligand identified mast cells as the possible producers of a ligand, When stimulated with an anti-Fc epsilon R1 antibody. cord blood-derived mast cells secreted factor(s) that induced Ca2+ mobilization in CRTH2-expressing K562 cells but not in mock transfected cells. These findings implied the involvement of CRTH2 in mast cell-mediated immune responses such as allergic reactions. (C) 1999 Federation of European Biochemical Societies.
引用
收藏
页码:195 / 199
页数:5
相关论文
共 26 条
[1]  
Aggarwal BB, 1995, HUMAN CYTOKINES THEI, P3
[2]   Comparative immunophenotypic analysis of human mast cells, blood basophils and monocytes [J].
Agis, H ;
Fureder, W ;
Bankl, HC ;
Kundi, M ;
Sperr, WR ;
Willheim, M ;
BoltzNitulescu, G ;
Butterfield, JH ;
Kishi, K ;
Lechner, K ;
Valent, P .
IMMUNOLOGY, 1996, 87 (04) :535-543
[3]   Chemokines and leukocyte traffic [J].
Baggiolini, M .
NATURE, 1998, 392 (6676) :565-568
[4]   CUTANEOUS LATE-PHASE RESPONSE TO ALLERGEN - MEDIATOR RELEASE AND INFLAMMATORY CELL INFILTRATION [J].
CHARLESWORTH, EN ;
HOOD, AF ;
SOTER, NA ;
KAGEYSOBOTKA, A ;
NORMAN, PS ;
LICHTENSTEIN, LM .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (05) :1519-1526
[5]   FLOW CYTOMETRIC EVALUATION OF HUMAN BASOPHILS [J].
GANE, P ;
PECQUET, C ;
LAMBIN, P ;
ABUAF, N ;
LEYNADIER, F ;
ROUGER, P .
CYTOMETRY, 1993, 14 (03) :344-348
[6]   Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils [J].
Gerber, BO ;
Zanni, MP ;
Uguccioni, M ;
Loetscher, M ;
Mackay, CR ;
Pichler, WJ ;
Yawalkar, N ;
Baggiolini, M ;
Moser, B .
CURRENT BIOLOGY, 1997, 7 (11) :836-843
[7]   PURIFICATION OF HUMAN-BLOOD EOSINOPHILS BY NEGATIVE SELECTION USING IMMUNOMAGNETIC BEADS [J].
HANSEL, TT ;
POUND, JD ;
PILLING, D ;
KITAS, GD ;
SALMON, M ;
GENTLE, TA ;
LEE, SS ;
THOMPSON, RA .
JOURNAL OF IMMUNOLOGICAL METHODS, 1989, 122 (01) :97-103
[8]  
ISHIZAKA T, 1984, PROG ALLERGY, V34, P188
[9]  
Macey MG, 1998, CYTOMETRY, V31, P199, DOI 10.1002/(SICI)1097-0320(19980301)31:3<199::AID-CYTO7>3.0.CO
[10]  
2-G