Host response to xenograft ECM implantation is not different between the shoulder and body wall sites in the rat model

被引:11
作者
Leigh, Diane R. [1 ,2 ]
Mesiha, Mena [3 ]
Baker, Andrew R. [1 ,2 ]
Walker, Esteban [4 ]
Derwin, Kathleen A. [1 ,2 ,3 ]
机构
[1] Cleveland Clin, Dept Biomed Engn, Lerner Res Inst, Cleveland, OH 44106 USA
[2] Cleveland Clin, Lerner Res Inst, Orthopaed Res Ctr, Cleveland, OH 44106 USA
[3] Cleveland Clin, Dept Orthopaed Surg, Cleveland, OH 44106 USA
[4] Cleveland Clin, Dept Quantitat Hlth Sci, Cleveland, OH 44106 USA
关键词
fascia lata ECM; host response; shoulder; gene expression; linear regression of efficiency; SMALL-INTESTINE SUBMUCOSA; EXTRACELLULAR-MATRIX; TENDON; AUGMENTATION; EXPRESSION; INFLAMMATION; SCAFFOLD; GRAFTS;
D O I
10.1002/jor.22149
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
100224 [整形外科学];
摘要
In the context of tendon and ligament repair, mechanical loading and the presence of joint synovial fluid are known to profoundly influence the form and function of the repair tissue and potentially the host response to biomaterials. Previously, we demonstrated that a xenograft extra cellular matrix (ECM) scaffold implanted in the rat shoulder elicited a unique host response from that seen in the body wall. However, the host response to xenografts implanted in shoulders with a tendon/capsule injury was not different from xenografts implanted in shoulders with no injury. In the current study, we hypothesized that varying clinically relevant surgical and environmental factors would introduce significant differences in host response to xenograft implantation at the shoulder. Contrary to our hypothesis, we found no significant differences in host response between any shoulder implantation conditions or between shoulder and body wall implantation in the rat model. These findings suggest that there is no advantage to using an orthotopic shoulder model to investigate the host response to rotator cuff scaffold materials in the rat model, and due to the insensitivity of its host response to various clinically relevant surgical conditions, may suggest that the rat does not provide a surrogate for directly translating the host response to biomaterials to the human application. (c) 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:17251731, 2012
引用
收藏
页码:1725 / 1731
页数:7
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