Flexibility in administration of fondaparinux for prevention of symptomatic venous thromboembolism in orthopaedic surgery

被引：50

作者：

Colwell, CW

Kwong, LM

Turpie, AGG

Davidson, BL

机构：

[1] Scripps Clin, Shiley Ctr Orthopaed Res & Educ, La Jolla, CA 92037 USA

[2] Univ Calif Los Angeles, Harbor Med Ctr, Dept Orthopaed, Torrance, CA 90509 USA

[3] Cedars Sinai Inst Joint Replacement, Los Angeles, CA USA

[4] McMaster Univ, Dept Internal Med, Hamilton, ON, Canada

[5] Univ Washington, Dept Pulm & Crit Care Med, Seattle, WA 98195 USA

[6] Swedish Med Ctr, Seattle, WA USA

来源：

JOURNAL OF ARTHROPLASTY | 2006年 / 21卷 / 01期

关键词：

venous thromboembolism; fondaparinux; total knee arthroplasty; administration timing;

D O I：

10.1016/j.arth.2005.05.023

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Venous thromboembolism (VTE) is a common complication of total joint arthroplasty. Fondaparinux VTE prophylaxis is currently begun 6 to 8 hours after surgery. Flexible dosing may reduce bleeding risk and allow easier use by starting the morning after surgery instead of staggered hours on the surgery day. This study examined flexible timing of the first dose of fondaparinux. Whether the first dose was administered 8 +/- 2 hours after surgery or the morning after surgery, no significant difference was observed in incidence of symptomatic VTE (2.0% and 1.9%, respectively, P =.89). Major and minor bleeding events were similar between groups (1.2% and 0.7% [P =.19], and 1.4% and 2.0% [P =.31], respectively). Delaying initiation of fondaparinux prophylaxis provides an option after total joint arthroplasty with preserved efficacy and safety.

引用

页码：36 / 45

页数：10

共 18 条

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