Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials

被引:132
作者
Ikeda, A [1 ]
Yazawa, S
Kunieda, T
Ohara, S
Terada, K
Mikuni, N
Nagamine, T
Taki, W
Kimura, J
Shibasaki, H
机构
[1] Kyoto Univ, Sch Med, Dept Brain Pathophysiol, Sakyo Ku, Kyoto 606, Japan
[2] Kyoto Univ, Sch Med, Dept Neurosurg, Sakyo Ku, Kyoto 606, Japan
[3] Kyoto Univ, Sch Med, Dept Neurol, Sakyo Ku, Kyoto 606, Japan
基金
日本学术振兴会;
关键词
pre-SMA; selection; voluntary movements; subdural recording; choice paradigm;
D O I
10.1093/brain/122.5.915
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
To clarify the functional role of human pre-supplementary motor area (pre-SMA) in 'cognitive' motor control as compared with other non-primary motor cortices (SMA-proper and lateral premotor areas) and prefrontal area, we recorded epicortical field potentials by using subdural electrodes in five epileptic patients during presurgical evaluation, whose pre-SMA, SMA-proper, prefrontal and lateral premotor areas were defined by electric cortical stimulation and recent anatomical orientations according to the bicommissural plane and callosal grid system. An S1-Go/NoGo choice and delayed reaction task (S1-choice paradigm) and a warned choice Go/NoGo reaction task (S2-choice paradigm) with inter-stimulus intervals of 2 s were employed. The results showed (i) transient potentials with onset and peak latencies of about 200 and 600 ms, respectively, after S1 in the S1-choice paradigm mainly at pre-SMA and to a lesser degree at the prefrontal and lateral premotor areas, but not in the S2-choice paradigm. At SMA-proper, a similar but much smaller potential was seen after S1 in both S1- and S2-choice paradigms and (ii) slow sustained potentials between S1 and S2 in both S1- and S2-choice paradigms in all of the non-primary motor areas investigated (pre-SMA, SMA-proper and lateral premotor areas) and prefrontal area. It is concluded that pre-SMA plays a more important role in cognitive motor control which involves sensory discrimination and decision making or motor selection for the action after stimuli, whereas SMA-proper is one of the main generators of Bereitschaftspotential preceding self-paced, voluntary movements. In the more general anticipation of and attention to the forthcoming stimuli, non-primary motor cortices including pre-SMA, SMA-proper and lateral premotor area, and the prefrontal area are commonly involved.
引用
收藏
页码:915 / 931
页数:17
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