Novel bioactive parathyroid hormone and related peptides in teleost fish

被引：32

作者：

Canario, AVM

Rotllant, J

Fuentes, J

Guerreiro, PM

Teodósio, HR

Power, DM

Clark, MS

机构：

[1] Univ Algarve, Ctr Ciencias Mar Algarve, P-8005139 Faro, Portugal

[2] Univ Maryland, Inst Biotechnol, Ctr Marine Biotechnol, Dev Biol Lab, Baltimore, MD 21202 USA

[3] MRC, Rosalind Franklin Ctr Genom Res, Cambridge CB10 1SB, England

来源：

FEBS LETTERS | 2006年 / 580卷 / 01期

基金：

英国医学研究理事会;

关键词：

parathyroid hormone; parathyroid hormone-related peptide; calciotropic; receptor; adenylate cyclase; phospholipase C;

D O I：

10.1016/j.febslet.2005.12.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodonfluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：291 / 299

页数：9

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